ReviewJournal of neurochemistry2025
Nitrergic Signaling Mediation of Neurobehavioral Responses to Stress in Zebrafish.
Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nitrergic Signaling Mediation of Neurobehavioral Responses to Stress in Zebrafish.Journal of neurochemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Nitric oxide (NO) is a gaseous transmitter that is involved in the regulation of multiple behavioral processes in the brain. Here, we review the participation of this molecule in zebrafish neurobehavioral responses to stress. NO signaling pathways are considerably conserved in this species, and different pathways appear to be related to the complex regulation of behavior by this molecule. NO acts as a downstream integrator of responses to different upstream signals, including glutamate, serotonin, and inflammatory mediators; as a result, it participates in both anxiolytic and anxiogenic effects of drugs acting at different targets. There is considerable evidence for the participation of both a glutamate/NOS-1 pathway and a KCNN/NOS-2 pathway in long-term behavioral sensitization to stress in zebrafish, suggesting that this molecule regulates metaplasticity in circuits that mediate defensive responses. Important questions remain unanswered, including the relationship between NO signaling, oxidative stress, and neuroinflammation, as well as the actual mechanisms of metaplasticity in the zebrafish brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.