ArticleCirculation2025
Contemporary Burden of Cardiovascular Disease in Pregnancy: Insights From a Real-World Pregnancy Electronic Health Record Cohort.
Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence of multimorbidity during pregnancy: a systematic review and meta-analysis.Reproductive health · 2026Pooled it
- Cardiac Biomarkers and Pregnancy-Associated Cardiovascular Disease.Current cardiology reports · 2026Review
- Response to "Comment on Cancer Treatment Modalities and Female Fertility Preservation".Pharmacotherapy · 2026Article
- Pregnancy- the ultimate cardiovascular stress test.NPJ cardiovascular health · 2026Review
- Maternal Mortality and Cardio-Kidney-Metabolic Risk Factors Across High-Income Countries.JACC. Advances · 2026Article
- Cardiovascular-Related Maternal Mortality.Obstetrics and gynecology · 2026Review
- Cardio-Obstetrics Fundamentals for Fellows: A Digital Solution for Democratizing Cardio-Obstetric Education.JACC. Advances · 2026Article
- Advancing Maternal Health with Long-Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies.Clinical pharmacology and therapeutics · 2026Review
- Prediction of Pregnancy-Related Cardiovascular Outcomes Using Electrocardiogram-Based Deep Learning Estimation of Cardiorespiratory Fitness.JACC. Advances · 2026Article
- Association Between Changes in Maternal Age Distribution and Hypertensive Disorders of Pregnancy in the United States, 2011-2021.Circulation. Population health and outcomes · 2026Article
- Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women.Circulation · 2026Article
- Optimizing Heart Failure-Specific Disease Management Programs and Patient Care in Saudi Arabia: A Saudi Heart Association Position Statement.Journal of the Saudi Heart Association · 2026Article
- How to set up a pregnancy heart team.International journal of cardiology. Congenital heart disease · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundCardiac and vascular complications are the leading causes of maternal mortality and morbidity, but the contemporary burden of and secular trends in pregnancy-related cardiovascular complications are not well-characterized. We developed a multi-institutional electronic health record-based pregnancy cohort with rigorously defined cardiovascular outcomes to examine trends in prevalence of maternal cardiovascular comorbidities and cardiovascular disease (CVD) and incidence of pregnancy-related cardiovascular complications.
methodsWe identified pregnancy encounters that occurred between 2001 and 2019 from a primary care electronic health record cohort using International Classification of Diseases and Current Procedural Terminology codes. We used regular expressions to recover estimated gestational age from unstructured notes and used gestational age to define the pregnancy episode for each individual pregnancy. Leveraging this cohort, we quantified and examined trends in the prevalence of maternal cardiovascular comorbidities and CVD and incidence of cardiovascular complications in pregnancies over the course of 19 years of follow-up. We also compared clinical factors for pregnancies with and those without cardiovascular complications.
resultsOur pregnancy cohort comprised 56 833 pregnancies among 38 996 individuals (mean age at start of pregnancy, 32±5 years). Regular expressions recovered gestational age for 75% of pregnancies, with good correlation between gestational age ascertained by regular expressions versus manual review (Pearson
conclusionsIn a large-scale electronic health record-based pregnancy cohort, both the prevalence of maternal cardiovascular comorbidities and CVD as well as the incidence of pregnancy-related cardiovascular complications within 1 year postpartum increased over the course of 2 decades. Our findings demonstrate an alarming rise in pregnancy-related cardiovascular complications in a contemporary real-world setting and highlight pregnancy as a crucial life opportunity for cardiovascular health optimization.
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