ReviewEpigenomics2025
A father's legacy: the sperm epigenome, preimplantation development, and paternal environment.
Review in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paternal exposure to the environment can influence offspring phenotypes via a process known as intergenerational epigenetic inheritance. Such form of inheritance involves the sperm epigenome that is subjected to modifications by paternal exposure, which are carried from the father to the next generation. After fertilization, paternally inherited changes can manifest in the embryo and result in modified phenotypes later in life. To be long-lasting, these changes must either persist, escape the epigenetic reprogramming occurring after fertilization or be reinstated by guiding mechanisms during early development. This review discusses how the sperm epigenome instructs transcription and early embryonic development, and how environmental exposure can reshape this epigenetic information to influence developmental and transcriptional programs in the embryo. It addresses the patterns of penetrance in intergenerational epigenetic inheritance and considers how the sperm and embryonic epigenome can contribute to the variability of inherited phenotypes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.