ArticleVeterinary ophthalmology2026
Effects of Omidenepag Isopropyl Versus Latanoprost Eye Drops on Intraocular Pressure, Pupil Diameter, and Anterior Chamber Parameters in Normal Feline Eyes: A Pilot Study.
Article in Veterinary ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Effects of Topical Omidenepag Isopropyl on Intraocular Pressure and Pupil Diameter in Normal Dogs.Veterinary ophthalmology · 2026Article
- The role of prostanoids in the retina and optic nerve in health and disease.Progress in retinal and eye research · 2026Review
- Topical Omidenepag Isopropyl Lowers Intraocular Pressure in Normal and Glaucomatous Cats: A Pilot Study.Veterinary ophthalmology · 2026Article
- Effects of Omidenepag Isopropyl Versus Latanoprost Eye Drops on Intraocular Pressure, Pupil Diameter, and Anterior Chamber Parameters in Normal Feline Eyes: A Pilot Study.Veterinary ophthalmology · 2026Article
- Anterior Segment Measurements in Normal Cats Using Ultrasound Biomicroscopy.Veterinary sciences · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesThis study aimed to compare the effect of the newly developed selective prostaglandin E2 receptor agonist, omidenepag isopropyl (OMDI), and latanoprost on intraocular pressure (IOP), pupil diameter (PD), and anterior chamber parameters in normal feline eyes. ANIMAL STUDIED: Twenty-two client-owned cats (n = 44 normal eyes) were included in the study. PROCEDURE: IOP and PD were evaluated at baseline (0), 2, and 4 h after drug administration. Ultrasound biomicroscopy was employed to assess parameters such as the iridocorneal angle (ICA), area of the ciliary cleft (CCA), width of the ciliary cleft, mid-width of the ciliary cleft (mid-CCW), angle-opening distance, length of the ciliary cleft, ciliary muscle thickness (CMT), and scleral ciliary process angle.
resultsThe OMDI-treated eyes showed a significant reduction in IOP compared with normal control eyes, unlike latanoprost-treated eyes. Compared with the control eyes, latanoprost-treated eyes showed a significantly greater decrease in PD than OMDI-treated eyes. The OMDI-treated eyes demonstrated a statistically significant increase in mid-CCW and CCA compared with the latanoprost-treated eyes. Both the OMDI- and latanoprost-treated eyes showed an increase in ICA and CMT compared with the control eyes.
conclusionOMDI effectively reduced IOP in cats for at least 4 h without reducing PD. An increase in the CCA and mid-CCW, observed exclusively with OMDI, suggests that the hypotensive effect may be mediated by the conventional outflow pathway. Additionally, an increase in CMT in both the OMDI- and latanoprost-treated eyes may indicate an effect on the uveoscleral outflow pathway.
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