ArticleAnnals of medicine2025
Urinary and circulatory levels of plasticizer metabolites and their associations with renal function: a cross-sectional analysis of the NHANES cohort.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Micro- and Nanoplastic Pollution and Renal Health: Human Evidence, Mechanisms, and Clinical Implications.Journal of xenobiotics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlasticizers used in consumer products raise concerns for nephrotoxicity; while DEHP is well characterized, evidence for DEHTP and DiNP-particularly their metabolites-remains limited. We examined associations of five urinary metabolites-MEHHP/MECPP (DEHP), MEHHTP/MECPTP (DEHTP), and MONP (DiNP)-with renal endpoints in a nationally representative adult sample.
methodsWe analyzed 2,229 adults from NHANES 2015-2018 using multivariable linear and restricted cubic spline models for eGFR, and evaluated combined-exposure effects with WQS and BKMR; analyses were repeated with UACR as a secondary outcome.
resultsHigher MECPP and MEHHP were associated with lower eGFR, whereas positive associations for MECPTP and MEHHTP may reflect early glomerular hyperfiltration rather than benefit. As a secondary endpoint, UACR indicated early injury: MECPP increased UACR (
conclusionUrinary plasticizer metabolites are linked to altered renal endpoints. Heterogeneous exposure-response patterns support complementary outcomes and mixture methods; longitudinal and mechanistic studies are needed to clarify causality and inform risk management for emerging plasticizers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.