Evidence map›Paper›PMID 41047657›Full record

SynthesisGut microbes2025

Proton pump inhibitors are not associated with an increased risk of

Diana-Elena Floria, Mahmoud Obeidat, Szilárd Váncsa, Sarolta Beáta Kávási, László Földvári-Nagy, Péter Hegyi, Dániel Sándor Veres, Vasile-Liviu Drug, Bálint Erőss

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana-Elena FloriaCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0003-2727-9913
Mahmoud ObeidatCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-2861-2573
Szilárd VáncsaCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-9347-8163
Sarolta Beáta KávásiCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
László Földvári-NagyCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-3954-721X
Péter HegyiCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0003-0399-7259
Dániel Sándor VeresCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-9687-3556
Vasile-Liviu DrugCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-7596-2656
Bálint ErőssCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0003-3658-8427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Observational studies reported conflicting results regarding the association between proton pump inhibitors (PPIs) and intestinal dysbiosis. We assessed the risk of enteric infections, including

Indexed as

Clostridium InfectionsProton Pump InhibitorsAdultClostridioides difficileDysbiosisGastrointestinal MicrobiomeHumansRandomized Controlled Trials as TopicRisk FactorsProton Pump Inhibitorsacid-suppressionenterocolitisesomeprazoleInfectious colitislansoprazoleomeprazolepantoprazole

Identifiers

PMID41047657
PMCPMC12502825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.