Trial reportPhysiological reports2025
Effects of acute ketone monoester ingestion on heart rate, blood pressure and muscle sympathetic nerve activity at rest and stress in healthy adults.
Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of acute ketone monoester ingestion on heart rate, blood pressure and muscle sympathetic nerve activity at rest and stress in healthy adults.Physiological reports · 2025Trial
- Intermittent exogenous ketosis does not reduce acute mountain sickness during early terrestrial high-altitude acclimatization.European journal of applied physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Exogenous ketone supplementation can impact cardiovascular regulation, but the effects on muscle sympathetic nerve activity (MSNA) remain unknown. In a randomized, crossover, double-blind design, 19 participants (23 ± 4 years.; female: n = 9) ingested an oral ketone monoester (KME; 0.4 g/kg) or isocaloric, isovolumetric placebo. Blood pressure, heart rate, brachial artery blood flow, and MSNA (microneurography; n = 14) were assessed at rest before and after ingestion and during two laboratory stressors: 2-min static handgrip exercise and 2-min of mental arithmetic. Capillary β-hydroxybutyrate increased 20 and 40 min post KME ingestion versus placebo (both, p < 0.001). Compared to placebo, KME had no effects on resting mean arterial pressure (Placebo: 78.3 ± 9.3 to 80.2 ± 10.5 mmHg; KME: 76.3 ± 8.3 to 79.5 ± 8.8 mmHg; interaction p = 0.32), heart rate (Placebo: 64.6 ± 12.3 to 69.6 ± 11.0 bpm; KME: 65.3 ± 10.6 to 72.6 ± 11.3 bpm; interaction p = 0.30), or MSNA burst frequency (Placebo: 17.7 ± 7.3 to 17.7 ± 6.7 bursts/minute; KME: 17.5 ± 6.1 to 18.2 ± 7.0 bursts/minute; interaction p = 0.72). Resting brachial artery blood flow and vascular conductance changed over time but did not differ between conditions (interactions, both p > 0.40). Neuro-cardiovascular responses during exercise (interactions, all p > 0.72) or mental stress (interactions, all p > 0.44) did not differ between conditions. Compared to placebo, acute KME ingestion did not modulate neuro-cardiovascular measures at rest or during stress in healthy young adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.