ArticleFuture oncology (London, England)2025
Prognostic implications of cancer-associated fibroblasts and desmoplastic reaction in stage III colon cancer risk groups.
Article in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimRisk stratification is used to tailor adjuvant treatment in stage III colon cancer. Cancer associated fibroblasts (CAFs) and desmoplastic reaction (DR) contribute to tumor microenvironment and are associated with tumor progression. We aimed to assess the prognostic value of CAF markers and DR pattern in stage III colon cancer risk groups. MATERIALS AND
methodsPatients with curative surgery for stage III colon cancer were categorized as low-risk (pT1-3 and pN1) and high-risk (pT4 or pN2). Expressions of fibroblast activation protein α (FAPα), fibroblast specific protein-1 (S100A4) and α-smooth muscle actin (α-SMA) were evaluated semiquantitatively with H-scores. DR pattern was classified as immature, intermediate and mature. Cox regression models were used to determine hazard ratios (HRs) of prognostic factors.
resultsWithin the study cohort (n = 172), 98 patients had high-risk and 74 had low-risk disease. In the low-risk group, high FAPα expression independently predicted DFS (HR = 3.06, p = 0.02). In the high-risk group, immature DR was an independent prognostic factor for both DFS (HR = 1.99, p = 0.02) and OS (HR = 2.04, p = 0.02).
conclusionFAPα as a surrogate marker of CAFs and DR pattern may have distinct prognostic impacts in stage III colon cancer risk groups and be utilized to refine prognosis further in these patients.
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