Evidence map›Paper›PMID 41047572›Full record

SynthesisOral diseases2026

Adverse Events in Nonsurgical Facial Aesthetic Procedures: A Systematic Review and Meta-Analysis.

Vitória Maria Sousa Cruz, Sebastião Silvério Sousa-Neto, Caique Mariano Pedroso, Maria Eduarda Pérez-de-Oliveira, Ana Gabriela Costa Normando, Helen Kaline Farias Bezerra, Rafael Tomaz Gomes, Ana Carolina Prado-Ribeiro, Danyel Elias da Cruz Perez, Pablo Agustin Vargas and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vitória Maria Sousa CruzOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8060-1823
Sebastião Silvério Sousa-NetoOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8890-8723
Caique Mariano PedrosoOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-7504-7597
Maria Eduarda Pérez-de-OliveiraOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0003-3265-2671
Ana Gabriela Costa NormandoOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0307-4991
Helen Kaline Farias BezerraOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5236-8988
Rafael Tomaz GomesPrivate Practice, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4210-2684
Ana Carolina Prado-RibeiroDental Oncology Service, Instituto Do Câncer Do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0127-7998
Danyel Elias da Cruz PerezOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4591-4645
Pablo Agustin VargasOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1840-4911
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2040-6617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the prevalence and clinical profile of treatment-related adverse events (TRAE) associated with: (1) botulinum toxin in the upper face; (2) hyaluronic acid fillers in the lower face and nasolabial folds; and (3) nonsurgical facelifts with absorbable threads.

methodsSearches were conducted in five electronic databases and gray literature. Proportion meta-analyses were performed to estimate the prevalence of TRAE for each type of aesthetic procedure.

results42 studies were included. TRAEs were reported in 34.8% of included patients. The highest TRAEs prevalence was associated with hyaluronic acid fillers (63.0%, 95% CI: 35%-84%), followed by nonsurgical facelifts with absorbable threads (20.0%, 95% CI: 8%-41%) and botulinum toxin in the upper face (18.0%, 95% CI: 10%-32%). The most frequently reported TRAEs were swelling (22.4%) and pain (19.0%) for hyaluronic acid fillers; pain (31.5%) and bruising (23.4%) for nonsurgical facelifts with threads; and headache for botulinum toxins. Hyaluronic acid fillers accounted for 67.3% of all TRAEs (n = 3729/4971).

conclusionsThe overall prevalence of adverse events was low for botulinum toxin and thread lifts, but high for hyaluronic acid fillers. Future studies should report all adverse events, expected and not expected, detailing the number of patients affected, total events, onset and recovery times, severity, and provider category.

Indexed as

Botulinum ToxinsCosmetic TechniquesDermal FillersFaceHyaluronic AcidHumansBotulinum ToxinsDermal FillersHyaluronic Acidadverse eventsbotulinum toxinshyaluronic acid fillersmeta‐analysissystematic reviewthread lifting

Identifiers

PMID41047572
PMCPMC13077022

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.