SynthesisThe Journal of laryngology and otology2025
Tranexamic acid can reduce blood loss and improve visibility in otological surgeries: a systematic review and meta-analysis of randomised controlled trials.
Synthesis in The Journal of laryngology and otology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of the study was to determine the effect of tranexamic acid in ear surgeries on duration of surgery, intra-operative blood loss, visibility and mean arterial pressure (MAP).
methodsA systematic review and meta-analysis were conducted following the 2020 PRISMA guidelines. Five databases were used (PubMed, Cochrane, Scopus, Web of Science and Embase). A search yielded 73 articles: 31 were duplicates and 42 were screened for by two authors. A standardised mean difference (SMD) was calculated to measure the effect size across studies.
resultsThe search yielded five final studies with ear procedures including tympanoplasty, atticotomy, mastoidectomy, ossiculoplasty, stapedotomy, tympanotomy and microscopic modified radical mastoidectomy. Tranexamic acid reduced duration of surgery (standardised mean difference = -3.82;
conclusionThis meta-analysis demonstrated that tranexamic acid reduced bleeding and mean arterial pressure that were both statistically significant, while the reduction in duration of surgery was statistically insignificant. All studies reported better visibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.