Evidence map›Paper›PMID 41047470›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation.

Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  2. Review
  3. Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruoyu ZhaoStroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, 130021, P. R. China.
Bin SunJoint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, First Hospital of Jilin University, Changchun, 130021, P. R. China.
Pengju WeiInstitute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Xueyuan Avenue 1068, Nanshan, Shenzhen, Guangdong, 518055, P. R. China.
Yingying SunStroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, 130021, P. R. China.
Qianyan HeStroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, 130021, P. R. China.
Kejia ZhangStroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, 130021, P. R. China.
Jun LuStroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, 130021, P. R. China.
Shoujun ZhuJoint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, First Hospital of Jilin University, Changchun, 130021, P. R. China.
Yi YangStroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, 130021, P. R. China.
Zhenni GuoStroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, 130021, P. R. China.ORCID https://orcid.org/0000-0002-8922-3862

Funding

Jilin Provincial Key Laboratory YDZJ202302CXJD017National Natural Science Foundation of China 32200785National Natural Science Foundation of China 82271303Norman Bethune Health Science Center of Jilin University 2025JBGS02Science and Technology Department of Jilin Province 20220303002SFScience and Technology Department of Jilin Province YDZJ202302CXJD061Talent Reserve Program of the First Hospital of Jilin University JDYYCB-2023002
6 · The paper itself

Abstract

The glymphatic system is essential for maintaining fluid homeostasis and clearing metabolic waste in the brain. Existing evidence suggests that this system is disrupted by systemic inflammation; however, the pathological characteristics and mechanisms underlying this disruption remain unclear. Near-infrared II imaging reveals an excessive increase in perivascular cerebrospinal fluid (CSF) influx and a reduction in CSF efflux, accompanied by impaired glymphatic clearance within 72 h in mice intraperitoneally injected with lipopolysaccharide (LPS) at a dose of 5 mg kg

Indexed as

BrainCerebrovascular CirculationGlymphatic SystemInflammationAnimalsAquaporin 4Blood-Brain BarrierDisease Models, AnimalLipopolysaccharidesMaleMiceMice, Inbred C57BLSimendanAquaporin 4LipopolysaccharidesSimendancerebral blood flowglymphatic systemlevosimendannear‐infrared II fluorescence imagingsepsis‐associated encephalopathysystemic inflammation

Identifiers

PMID41047470
PMCPMC12713049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.