Evidence map›Paper›PMID 41047454›Full record

ReviewMolecular biomedicine2025

Atopic dermatitis: diagnosis, molecular pathogenesis, and therapeutics.

Ruimin Bai, Yan Zheng, Xiaofeng Dai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
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  7. Review
  8. Review
  9. Epithelial-Dermal Immune Memory: TrackingInternational journal of molecular sciences · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Oxidative and Nitrosative Stress in Atopic Dermatitis and Depression: Similarities in Biomarkers and Pathophysiological Mechanisms.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  14. Aeroallergens in Atopic Dermatitis and Chronic Urticaria.Current allergy and asthma reports · 2026
    Review
  15. Review
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ruimin Bai *Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, No.277 Yanta West Road, Xi'an, Shaanxi, 710061, China.ORCID http://orcid.org/0000-0002-1691-7521
Yan Zheng *Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, No.277 Yanta West Road, Xi'an, Shaanxi, 710061, China.ORCID http://orcid.org/0000-0002-1380-3211
Xiaofeng DaiNational Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, No.277 Yanta West Road, Xi'an, Shaanxi, 710061, China. xiaofengteam@163.com.ORCID http://orcid.org/0000-0001-5323-7886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by acute and chronic phases with no definitive cure currently available. The diagnosis of AD involves the evaluation of both disease onset and severity, relying on established clinical criteria and, increasingly, on various biomarkers to improve diagnostic accuracy. The molecular pathogenesis of AD is driven by a combination of genetic predispositions, environmental factors, and immune dysregulation. Acute AD is predominantly mediated by T-helper cell 2 (Th2) immune responses, whereas chronic AD involves a shift toward Th1-driven inflammation. Within this immunological context, we emphasize the role of redox imbalance in disease progression and propose a wound-healing model to explain the molecular dynamics of AD. According to this model, the acute phase is marked by excessive oxidative stress, requiring antioxidant intervention, whereas the chronic phase is characterized by insufficient redox signaling, which hinders the clearance of hyperproliferative cells. We further review current and emerging therapeutic strategies, including anti- and pro-oxidative strategies, based on the different AD staging. Notably, we introduced cold atmospheric plasma (CAP), a redox regulatory tool, as a novel treatment modality for AD management that stimulates antioxidant responses at low to moderate doses and induces oxidative stress at higher concentrations, potentially reversing chronic AD pathology. This review offers a comprehensive overview of AD, from clinical manifestations and molecular pathogenesis to therapeutic approaches, and introduces the 'wound healing model' as a conceptual framework to integrate CAP as an innovative treatment modality for AD management and to inform future research.

Indexed as

Dermatitis, AtopicAnimalsAntioxidantsBiomarkersHumansOxidation-ReductionOxidative StressAntioxidantsBiomarkersAtopic dermatitisCold atmospheric plasmaDiagnosisPathogenesisTherapeuticsWound healing model

Identifiers

PMID41047454
PMCPMC12497682

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.