SynthesisClinical oral investigations2025
Effect of disinfection and tissue repair with chloramphenicol-tetracycline-ZOE paste on pulp therapy of primary teeth: a systematic review.
Synthesis in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Internal root resorption: understanding the pink tooth of mummery and its clinical implications.Journal of clinical and experimental dentistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis systematic review evaluated the effectiveness of the disinfection and tissue repair technique using chloramphenicol-tetracycline-zinc oxide eugenol paste (CTZ) in pulp therapy of primary teeth.
methodsFollowing PRISMA 2020 guidelines and PROSPERO registration, comprehensive searches were conducted in multiple databases. Eligibility criteria included clinical studies evaluating CTZ paste in children with pulp necrosis in primary teeth. Risk of bias was assessed using the Cochrane tool for randomized trials and the Newcastle-Ottawa Scale for non-randomized studies. Certainty of evidence was assessed using GRADE.
resultsTen studies, including 496 children aged 3-8 years, met the inclusion criteria. CTZ paste showed high clinical success rates (~ 90-100%) and radiographic success ranging from 72% to 100%. Compared to alternative treatments such as zinc oxide eugenol, 3Mix-MP, formocresol, Guedes-Pinto paste, and pulpectomy, CTZ showed similar outcomes in most comparisons. Additional advantages included reduced postoperative pain, simpler application, and lower procedural costs, suggesting its practicality in pediatric endodontics. Overall, studies presented a low risk of bias. Certainty of evidence was rated moderate for randomized trials and low for non-randomized studies.
conclusionCTZ paste demonstrates potential as an effective and cost-efficient therapeutic option for the treatment of necrotic primary teeth, showing high clinical and radiographic success rates. Further well-designed, long-term randomized controlled trials are needed to confirm these findings. CLINICAL RELEVANCE: CTZ paste offers simplified, cost-effectiveness, and high success rates make it valuable in pediatric dentistry, especially for uncooperative children and in low-resource settings where conventional endodontic techniques may be unfeasible.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.