Nilotinib hydrochloride monohydrate solubility in supercritical carbon dioxide + cosolvent: measurements and modeling.

Seyed Ali Sajadian, Adel Noubigh, Mahshid Askarizadeh, L Antonio Estévez

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Integrating experimental data and machine learning models for solubility prediction of yellow 23 in supercritical carbon dioxide.RSC advances · 2025
Article

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5 · Who and what money

Authors and funding

4 authors.

Seyed Ali SajadianDepartment of Chemical Engineering, Faculty of Engineering, University of Kashan, Kashan, 87317-53153, Iran. seyedali.sajadian@gmail.com.

Adel NoubighCenter for Scientific Research and Entrepreneurship, Northern Border University, Arar, 73213, Saudi Arabia.

Mahshid AskarizadehDepartment of Chemical Engineering, Marv.C., Islamic Azad University, Marvdasht, Iran.

L Antonio EstévezDepartment of Chemical Engineering, University of Puerto Rico, Mayagüez, 00681-9000, Puerto Rico. antonio.estevez@upr.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The solubility of nilotinib hydrochloride monohydrate in supercritical CO₂ was measured at four temperatures between 338 K and 308 K, and seven pressures between 12 MPa and 30 MPa, using ethanol as a cosolvent. Both semi-empirical and empirical approaches were employed to analyze the experimental data. In the ternary systems studied, the solubility values (mole basis) for nilotinib hydrochloride monohydrate were between 1.08 × 10

Indexed as

CosolventNilotinib hydrochloride monohydrateSemi-empirical modelingSolubility measurementSupercritical carbon dioxide

Identifiers

PMID41047398

DOI10.1038/s41598-025-20081-y

PMCPMC12497881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.