Evidence map›Paper›PMID 41047394›Full record

ArticleChinese medicine2025

Epigenetic control of the plant metabolome: implications for Chinese medicine.

Tae Kyung Hyun

Abstract readLetter
In one paragraph

Article in Chinese medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Tae Kyung HyunDepartment of Industrial Plant Science and Technology, College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju, 28644, Republic of Korea. taekyung7708@chungbuk.ac.kr.

Funding

Cooperative Research Program for Agriculture Science and Technology Development RS-2022-RD010345
6 · The paper itself

Abstract

Epigenetic regulation-including DNA methylation, histone modifications, and small RNAs-plays a crucial role in modulating specialized metabolism in plants; specialized metabolites confer crucial pharmacological properties to plants, forming the basis of traditional Chinese medicine (TCM). Recent studies have highlighted the influence of these mechanisms on metabolite production in key medicinal plants such as Papaver somniferum and Salvia miltiorrhiza. Emerging technologies such as CRISPR/dCas9-based epigenome editing and miRNA modulation enable precise control of biosynthetic pathways. Integrating these molecular-level strategies into TCM research and the cultivation of medicinal plants could improve the efficacy and consistency of herbal medicinal products, providing molecular tools for the targeted regulation of active ingredients and thereby facilitating the modernization of TCM.

Indexed as

DNA methylationEpigenetic regulationHistone modificationSmall RNAsSpecialized metabolism

Identifiers

PMID41047394
PMCPMC12498456

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.