ArticleThe world journal of men's health2026
The Biomolecular Effects of Finasteride on Male Rat Brain During Administration and After Discontinuation.
Article in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- Intratesticular and peritesticular methylene blue injection in visualizing lymphatic vessels and its impact on testicular injury in rat testes.Pediatric surgery international · 2025Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
purposeThis study aimed to investigate the biomolecular effects of finasteride on rat brain tissue during and after discontinuation. MATERIALS AND
methodsTwenty-four 14-week-old male Wistar rats were randomly assigned to three groups: Group 1 (control), Group 2 (finasteride-treated), and Group 3 (finasteride-withdrawn). Serum testosterone and dihydrotestosterone levels were measured at the end of the study period. Brain tissues were analyzed using real-time polymerase chain reaction (RT-PCR), western blotting, and immunohistochemistry, with c-Fos employed as a non-specific biomarker of neural cellular activity.
resultsIn Group 2, serum dihydrotestosterone levels, 5-alpha reductase type 1 protein expression, and c-Fos phosphorylation showed a decreasing trend (p=0.067, p=0.015, p=0.123, respectively, versus Group 1), but rebounded in Group 3 (p=0.044, p=0.033, p=0.049, respectively, versus Group 2). In contrast, 5-alpha reductase type 2 protein expression was significantly reduced in Group 2 (p=0.017
conclusionsSuppression of c-Fos-related neural activity in rat brain tissue could be temporarily maximized by both type 1 and type 2 5-alpha reductase inhibition by finasteride administration, and this suppression could be relieved by the restoration of 5-alpha reductase type 1 expression after finasteride discontinuation.
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