Trial reportPediatrics2025
Pediatric Clinician Adherence to Peanut Allergy Prevention Guidelines: A Randomized Trial.
Trial report in Pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Implementation of early peanut introduction among providers in a southern US state.The journal of allergy and clinical immunology. Global · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
BACKGROUND AND
objectivesThe 2017 US Addendum Guidelines for the Prevention of Peanut Allergy encourage clinicians to recommend early introduction of peanut-containing foods to infants' diets to prevent peanut allergy (PA). However, clinician guideline adherence has been low. The Intervention to Reduce Early Peanut Allergy in Children (iREACH) Trial aims to increase pediatric clinicians' adherence to the guidelines.
methodsiREACH is a practice-based, cluster randomized trial of 30 pediatric practices. Intervention practices received clinician education, a clinical decision support (CDS) tool embedded into electronic health record (EHR) systems, and visual aids, while those in the control arm did not. The primary outcome was clinician adherence to guidelines, documented in EHR data from 4- or 6-month well-child care visits. Clinicians were adherent for low-risk infants (no/mild/moderate eczema and no egg allergy) if they recommended the introduction of peanut-containing foods and, for high-risk infants (severe eczema and/or egg allergy), if they ordered a peanut-specific immunoglobulin E test and counseled appropriately or referred to an allergist.
resultsOverall, 18 480 infants (intervention, n = 9290; control, n = 9190) were seen by 290 clinicians. Among low-risk infants (n = 18 182), intervention clinicians were adherent for 83.7%, while control clinicians were adherent for 34.7% (odds ratio [OR], 14.6; 95% CI, 7.0-30.5; P < .001). Among high-risk infants (n = 298), intervention clinicians were adherent for 26.8%, while control clinicians were adherent for 10.4% (OR, 3.1; 95% CI, 1.1-8.8; P = .03).
conclusionsA multifaceted educational intervention improved clinician guideline adherence. Wide dissemination of the intervention and implementation of the guidelines could reduce the incidence of PA.
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Registered trials
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