ArticleTransplantation and cellular therapy2026
Search Summary Score: A Global Measure to Predict Matched Unrelated Stem Cell Donor Availability.
Article in Transplantation and cellular therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- System-level Redesign of an Allogeneic Hematopoietic Cell Transplantation Program Associated With High One-year Survival and Reduced Cost.Transplantation and cellular therapy · 2026Article
- Addressing racial disparities in representation across blood, stem cell and organ and tissue donor pools.Vox sanguinis · 2026Review
- Optimal donor selection for transplant to reduce GVHD risk and augment graft-versus-malignancy efficacy.Current opinion in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFinding a suitably HLA-matched unrelated donor (URD) is essential for successful hematopoietic stem cell transplant (HSCT). Existing search productivity measures do not - or only partially - address real-world donor availability which can greatly affect a patient's transplant timeline.
objectiveThis study aims to improve upon existing scores to provide a more accurate assessment of unrelated donor search productivity. STUDY
designSearch Summary Score (SSS) is a novel metric that integrates NMDP HapLogic
resultsSSS was validated using 18 222 URD searches from 2021 to 2024, achieving superior predictive accuracy compared to NMDP Search Prognosis and 8/8 URD Search Prognosis (v1.0 and v2.0). For predicting 8/8 matches, SSS demonstrated an AUC of 0.962 and F1 score of 0.96. SSS utility is illustrated in examples of distinguishing clinically meaningful scenarios within the same Search Prognosis category.
conclusionsSSS offers an interpretable, scalable, and globally applicable tool to assess matched donor availability at the initiation of search. By integrating both HLA compatibility and real-world donor readiness, SSS enhances clinical decision-making, promotes equity in donor access, and supports earlier planning for efficient selection of alternative graft sources.
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Registered trials
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