Evidence map›Paper›PMID 41046765›Full record

ArticleThe Journal of surgical research2025

Effects of Early Palliative Care Involvement on More At-Risk Patients Undergoing Surgery for Cancer.

Peter A Bryant, Onur M Orun, Rameela Raman, Myrick C Shinall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peter A BryantDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Center for Biomedical Ethics and Society, Vanderbilt University, Nashville, Tennessee. Electronic address: Peter.bryant@vumc.org.
Onur M OrunDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Rameela RamanDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Myrick C ShinallDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Geriatrics Research Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee; VETWISE Center of Innovation, VA Tennessee Valley Healthcare System, Nashville, Tennessee.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Surgical Oncology Training GrantT32CA106183 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI James Richard Goldenring · 2004 to 2026
$6.0M
Specialist Palliative Care in Surgical OncologyK76AG068436 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHINALL, MYRICK C · 2020 to 2022
$714k
The Surgery for Cancer with Option of Palliative Care Expert (SCOPE) TrialR03AG060085 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHINALL, MYRICK C · 2018 to 2019
$237k
NCATS NIH HHS UL1 TR002243NCI NIH HHS K12 CA090625NCI NIH HHS T32 CA106183NIA NIH HHS K76 AG068436NIA NIH HHS L30 AG064684NIA NIH HHS R03 AG060085
6 · The paper itself

Abstract

introductionTwo recent clinical trials of patients undergoing nonpalliative surgery for abdominal malignancies found no benefit from early specialist palliative intervention. However, more at-risk patients may benefit from this intervention.

methodsThis secondary, post-hoc exploratory analysis of data from one of these trials examines heterogeneity of treatment effect to identify at-risk subgroups of patients who benefit from early specialist palliative intervention. Regression models with interaction terms between treatment and age, frailty, and baseline values of patient reported outcomes (PROs) were used to examine heterogeneity of treatment effect for five PROs at 90 d postoperatively.

resultsAt alpha = 0.2, there was evidence of possible heterogeneity of treatment effect in six models: by age for the outcomes of physical and functional quality of life (P = 0.12), anxiety (P = 0.03), and depression (P = 0.01); by baseline PRO value for the outcomes of physical and functional quality of life (P = 0.04), anxiety (P = 0.19), and life space (P = 0.03). Graphical examination did not reveal a consistent pattern of more positive intervention effects for more at-risk patients.

conclusionsWe found no consistent pattern in heterogeneity of effect to suggest a particular subgroup benefitting from early specialist palliative intervention. This further supports the conclusion that the palliative care needs of these patients are met by their usual care teams.

Indexed as

Abdominal NeoplasmsPalliative CareAdultAgedAged, 80 and overAnxietyFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresQuality of LifeTreatment OutcomeClinical trialHeterogeneity of treatment effectNeoplasmsPalliative careQuality of lifeSurgerySurgical oncology

Identifiers

PMID41046765
PMCPMC12591275

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.