ArticleThe Journal of surgical research2025
Effects of Early Palliative Care Involvement on More At-Risk Patients Undergoing Surgery for Cancer.
Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Surgery-Type and Dose-Response Analysis of Palliative Care in Patients Undergoing Surgery for Cancer.Annals of surgical oncology · 2026Article
- A Novel Integrated Surgeon-led Palliative Surgical Oncology and Prehabilitation Care Delivery Model for Individuals with Advanced Cancer Undergoing Major Surgery.Annals of surgical oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
introductionTwo recent clinical trials of patients undergoing nonpalliative surgery for abdominal malignancies found no benefit from early specialist palliative intervention. However, more at-risk patients may benefit from this intervention.
methodsThis secondary, post-hoc exploratory analysis of data from one of these trials examines heterogeneity of treatment effect to identify at-risk subgroups of patients who benefit from early specialist palliative intervention. Regression models with interaction terms between treatment and age, frailty, and baseline values of patient reported outcomes (PROs) were used to examine heterogeneity of treatment effect for five PROs at 90 d postoperatively.
resultsAt alpha = 0.2, there was evidence of possible heterogeneity of treatment effect in six models: by age for the outcomes of physical and functional quality of life (P = 0.12), anxiety (P = 0.03), and depression (P = 0.01); by baseline PRO value for the outcomes of physical and functional quality of life (P = 0.04), anxiety (P = 0.19), and life space (P = 0.03). Graphical examination did not reveal a consistent pattern of more positive intervention effects for more at-risk patients.
conclusionsWe found no consistent pattern in heterogeneity of effect to suggest a particular subgroup benefitting from early specialist palliative intervention. This further supports the conclusion that the palliative care needs of these patients are met by their usual care teams.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.