Evidence map›Paper›PMID 41046487›Full record

ReviewHuman cell2025

Emerging role of the E3 ubiquitin ligase RNF114 in health and disease.

Qian Wang, Shihan Cao, Zhenzhen Sun, Zhanjun Jia, Shiwei Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qian WangDepartment of Cardiology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Shihan CaoDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhenzhen SunDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China. sunzzjjhh@163.com.
Zhanjun JiaDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China. jiazj72@hotmail.com.ORCID http://orcid.org/0000-0002-3107-0429
Shiwei YangDepartment of Cardiology, Children's Hospital of Nanjing Medical University, Nanjing, China. jrdoctoryang@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ubiquitination plays important roles in various biological processes and diseases by affecting the subcellular localization, function, and degradation of substrates. Multiple ubiquitin-associated enzymes jointly mediate the binding of ubiquitin to substrates. Over the past few decades, numerous E3 ubiquitin ligases, including RING finger protein 114 (RNF114), have been well studied. Research has revealed the involvement of RNF114 in various biological processes, including embryonic development, the cell cycle, genome stability, the immune response, and osteoclastogenesis. Additionally, RNF114 is implicated in multiple diseases, such as viral infections, psoriasis, liver fibrosis, and cancer. This review recapitulates the most recent advances regarding RNF114 and provides possible directions for future research.

Indexed as

DiseaseUbiquitin-Protein LigasesAnimalsCell CycleEmbryonic DevelopmentGenomic InstabilityHumansLiver CirrhosisNeoplasmsPsoriasisUbiquitinationVirus DiseasesUbiquitin-Protein LigasesDegradationDiseasePhysiologyRNF114Ubiquitination

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.