Evidence map›Paper›PMID 41046318›Full record

ReviewCellular & molecular biology letters2025

Endogenous cardiac catecholaminergic systems in cardiac development, physiology, and pathophysiology.

Yuqing Zheng, Rina Yue Ren, Xingyue Wu, Fuzhi Qu, Alexander Grassam-Rowe, Tianyi Sun, Xianhong Ou, Xiaoqiu Tan, Minghe Huang, Ming Lei

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular & molecular biology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuqing Zheng *Department of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Rina Yue Ren *Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3Q, UK.
Xingyue Wu *Department of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Fuzhi QuDepartment of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Alexander Grassam-RoweDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3Q, UK.
Tianyi SunDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3Q, UK.
Xianhong OuKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Xiaoqiu TanDepartment of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Minghe HuangGulf Coast Heart Clinic, 9600 Bellaire Blvd, Suite 202, Houston, TX, 77036, USA. mhuang1458@aol.com.
Ming LeiKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China. ming.lei@pharm.ox.ac.uk.ORCID http://orcid.org/0000-0002-0928-341X

Funding

British Heart Foundation PG/21/10512British Heart Foundation PG/22/11217British Heart Foundation PG/23/11479National Natural Science Foundation of China 31871181National Natural Science Foundation of China 82270334National Natural Science Foundation of China 82470323Sichuan Provincial Youth Science and Technology Foundation 025HJPJ0005; No. 2024JDHJ0051Sichuan Provincial Youth Science and Technology Foundation 2024JDJ0051Sichuan Provincial Youth Science and Technology Foundation 2025HJPJ0005
6 · The paper itself

Abstract

Catecholamines, canonically associated with the sympathetic nerves and the adrenal medulla, are also produced by neuroparacrine cells within the heart. Despite their putative importance, the precise functions of these neuroparacrine cells in the heart are not well understood and their clinical implications remain to be defined. In this review, we first explore the historical context and recent advances in research on intrinsic cardiac adrenergic (ICA) cells, focusing on their unique characteristics, distributions, and progenitor-like potential during cardiac development. We then examine their contributions to both physiological and pathological cardiac states. We further discuss a recently identified population of catecholaminergic cardiomyocytes; we discuss their involvement in cardiac development, maturation, and their potential interaction with sympathetic innervation during development. By reviewing these findings, we provide new insights into the endogenous production of catecholamines within the heart and its relevance to cardiac development, physiology and disease, and its potential clinical implications.

Indexed as

CatecholaminesHeartMyocardiumAnimalsHeart DiseasesHumansMyocytes, CardiacCatecholaminesCatecholaminergic cardiomyocytesCatecholaminesDbhIntrinsic cardiac adrenergic cellsPnmt

Identifiers

PMID41046318
PMCPMC12497348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.