Functional effects of heavy metal exposures on N6-methyladenosine (m6A) methylation and other Epitranscriptomic modifications in the central nervous system.

Niraj Lodhi, Lauren Powell, Jay S Schneider

Abstract readReview

In one paragraph

Review in Neurochemistry international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Niraj LodhiDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA. Electronic address: niraj.lodhi@jefferson.edu.

Lauren PowellDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

Jay S SchneiderDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

Funding

The Role of m6A-RNA Methylation in Memory Formation and Recall and Its Modulation and Influence on Long-Term Outcomes as a Consequence of Early Life Lead ExposureR01ES034077 · NIEHS · THOMAS JEFFERSON UNIVERSITY · PI Niraj Lodhi · 2023 to 2026

$2.2M

NIEHS NIH HHS R01 ES034077

6 · The paper itself

Abstract

Among different RNA methylations, N6-methyladenosine (m6A) is the most abundant in the brain and determines the fate of RNA through reversible processes using methyltransferases, demethylases, and methyl-binding proteins. The reversibility of m6A is an emerging regulatory mechanism for gene expression, regulating many aspects of RNA metabolism and influencing learning and memory processes. Global m6A profiles are dynamically modified via the activity of various writers, readers, and erasers. However, m6A alterations from exposure to heavy metals, including the metals lead (Pb), cadmium (Cd), cobalt (Co), and manganese (Mn) and the metalloid arsenic (As), and the impact on brain function, are not fully understood. This paper reviews recent work that may begin to shed light on how heavy metal exposures may affect m6A methylation and how this might impact central nervous system functioning.

Indexed as

AdenosineCentral Nervous SystemEnvironmental ExposureEpigenesis, GeneticMetals, HeavyAnimalsHumansMethylationAdenosineMetals, HeavyN-methyladenosineArsenic (As)Cadmium (Cd)Cobalt (co)EpitranscriptomicsHeavy metalsLead (Pb)Manganese (Mn)N6-methyladenosine (m6A)

Identifiers

PMID41046059

DOI10.1016/j.neuint.2025.106064

PMCPMC13077640

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.