Evidence map›Paper›PMID 41045932›Full record

ArticleCell reports. Medicine2025

In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence.

Ciliang Guo, Tian Gao, Bin Xue, Louqian Zhang, Shuo Wang, Rongrong Xiao, Lingkai Kong, Yuxin Zhang, Qilei Xin, Yi Cao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ciliang GuoState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China.
Tian GaoCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210093, China.
Bin XueJinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China; Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210093, China.
Louqian ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Shuo WangState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China.
Rongrong XiaoState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China.
Lingkai KongState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Yuxin ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China.
Qilei XinJinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China.
Yi CaoJinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China; Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210093, China.
Xiaosong GuState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address: nervegu@ntu.edu.cn.
Chunping JiangState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province 362000, China; Renhuai People's Hospital, Renhuai, Guizhou Province 564055, China. Electronic address: chunpingjiang@nju.edu.cn.
Junhua WuState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Building 1, Jinan Medical and Health Science and Technology Innovation Industrial Park, No. 288, Jiqi Road, Huayin District, Jinan City, Shandong Province, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address: wujunhua@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative tumor recurrence represents a major challenge for patients. Oncolytic virus (OV) therapy has attracted increasing attention in recent years. Here, we construct a supramolecular hydrogel enabling extended release of type V oncolytic adenovirus (adv), with hydrogel stability confirmed experimentally. In situ treatment with the adv-loaded hydrogel (adv@Nap gel) instantly after tumor resection efficiently activates the type I interferon pathway, induces innate and adaptive immunity, controls postoperative tumor recurrence and metastasis, and prolongs mouse survival. We verify the ability of instant in situ treatment with adv@Nap gel to inhibit postoperative tumor recurrence. Notably, oncolytic herpes simplex virus or vaccinia virus loaded in Nap gel can also control postoperative tumor recurrence. Thus, hydrogel-loaded OVs that induce extended immune activation represent a paradigm for sustained antitumor immunotherapy, and in situ sustained immune activation initiated during surgery may represent an important and universal treatment guideline.

Indexed as

Neoplasm Recurrence, LocalNeoplasmsOncolytic VirotherapyOncolytic VirusesAdenoviridaeAnimalsCell Line, TumorFemaleHumansHydrogelsImmunotherapyMiceMice, Inbred BALB CMice, Inbred C57BLVaccinia virusHydrogelsanti-tumor immunityhydrogelimmune activationoncolytic adenovirusoncolytic virussupramolecular hydrogelsustained releasetumor immunotherapytumor recurrencetype I interferon pathway

Identifiers

PMID41045932
PMCPMC12629831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.