Evidence map›Paper›PMID 41045465›Full record

ArticleUnited European gastroenterology journal2025

Mortality Prediction by Bedside Rectus Femoris Muscle Ultrasound for Sarcopenia Diagnosis in Liver Cirrhosis.

Sara De Monte, Philipp Altmann, Svenja Pichlmeier, Hans Benno Leicht, Sophia Stuhlreiter, Roswitha Brandl, Florian P Reiter, Sigrid Hahn, Clemens Benoit, Andreas Geier and 2 more

Abstract read
In one paragraph

Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara De MonteDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Philipp AltmannDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Svenja PichlmeierDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany.
Hans Benno LeichtDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Sophia StuhlreiterDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Roswitha BrandlDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Florian P ReiterDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Sigrid HahnDepartment of Nutritional, Food and Consumer Sciences, University of Applied Siences Fulda, Fulda, Germany.
Clemens BenoitDivision of Pediatric Radiology, Department of Radiology, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-0589-9356
Andreas GeierDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Mathias PlauthDepartment of Internal Medicine, Dessau Community General Hospital, Dessau-Rosslau, Germany.ORCID https://orcid.org/0000-0002-7731-9365
Monika RauDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0003-1219-4044

Funding

German Association of Nutrition Medicine
6 · The paper itself

Abstract

backgroundSarcopenia is common in patients with liver cirrhosis and is an independent predictor of morbidity and mortality. This prospective study assessed the performance of rectus femoris muscle (RFM) ultrasound in patients with liver cirrhosis to identify those at risk for sarcopenia as defined by the combination of low muscle mass and low muscle strength.

methods84 patients with liver cirrhosis hospitalized at a tertiary center (05/22-02/24) were included with 6-month follow-up. Within 24-48 h of admission hand grip strength, chair rise test (CRT), timed up and go (TUG), short physical performance battery (SPPB), rectus femoris muscle ultrasound, and bioelectrical impedance analysis (BIA) were assessed. Statistical analyses included receiver operating characteristic (ROC) curves, Kaplan-Meier estimates, Cox regression, and competing risk analyses.

resultsMost (73.8%) patients had decompensated and mainly alcohol-related liver cirrhosis. Thickness and cross-sectional area of rectus femoris muscle (MT

conclusionRectus femoris muscle ultrasound is a feasible bedside method for identifying patients with liver cirrhosis at risk of sarcopenia. Sarcopenia as diagnosed by prolonged CRT together with low RFM mass by ultrasound is an independent predictor for 6-month mortality, highlighting the clinical utility of RFM ultrasound in diagnosing sarcopenia.

Indexed as

Liver CirrhosisQuadriceps MuscleSarcopeniaAgedElectric ImpedanceFemaleHand StrengthHumansKaplan-Meier EstimateMaleMiddle AgedMuscle StrengthPoint-of-Care TestingPredictive Value of TestsProspective StudiesROC Curvechair rise testliver cirrhosismorbiditymortalitymuscle functionpredictionrectus femoris musclesarcopeniaultrasound

Identifiers

PMID41045465
PMCPMC12704570

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.