ArticleApplied biochemistry and biotechnology2025
Investigation of the Interaction Mechanisms of Melatonin, N-Acetylserotonin, and 5-Methoxytryptamine with DNA, Cholinesterase Inhibitory Activity, and Antioxidant Properties.
Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this study, the interaction of melatonin (ME) and its metabolites 5-Methoxytryptamine (MT) and N-Acetylserotonin (NAS) with fish sperm DNA (dsDNA) was investigated using various methods such as spectrophotometry, spectrofluorimetric and viscosity measurements. The results obtained demonstrated that these molecules exhibited a significant binding interaction with dsDNA. The intercalation binding mode was confirmed by competitive binding studies with ethidium bromide and rhodamine B, UV-Vis spectrophotometry and viscosity measurements. The molecules were also evaluated for their cholinesterase (AChE and BChE) inhibition properties in vitro. Compared to the reference drug donepezil, the molecules exhibited higher inhibitory activity. They showed high AChE inhibitory activity with IC
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