Evidence map›Paper›PMID 41045374›Full record

ReviewMolecular biology reports2025

Exosomes and their role in gastric cancer caused by Helicobacter pylori.

Adeleh Attar, Mahnaz Mohammadi, Mana Kamranjam, Safarali Alizadeh, Seyed Amir Farzam, Rasoul Samimi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances inOncology letters · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adeleh AttarMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.ORCID http://orcid.org/0000-0002-0307-9215
Mahnaz MohammadiMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Mana KamranjamCellular and Molecular Research Center, Research Institute for Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Safarali AlizadehMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Seyed Amir FarzamMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. afarzam@qums.ac.ir.ORCID http://orcid.org/0000-0001-5087-9381
Rasoul SamimiMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. samimirasoul2@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori (H. pylori) is one of the main pathogens linked to the etiology of gastric cancer (GC) and the cause of a large portion of the world's disease burden. Exosomes, small extracellular vesicles, play a crucial role in the pathogenesis and progression of GC through their unique RNA cargo. Exosomes produced from H. pylori-infected cells carry bioactive chemicals such as MicroRNA (miRNAs), that rewire recipient cells, so modulating immune responses, promoting angiogenesis, facilitating metastasis, and contributing to treatment resistance. Here, the role of H. pylori in GC is discussed, with a focus on H. pylori-induced exosomal miRNAs in pathogenesis through regulation of gene expression, inflammatory responses, and the tumor microenvironment. This review underscores the importance of exosome-mediated cross-talk in H. pylori-induced GC as predictive diagnostic biomarkers. Moreover, their potential use in treatment approaches and the need for further research into exosome-based therapeutic strategies will be highlight.

Indexed as

ExosomesHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsAnimalsBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMicroRNAsTumor MicroenvironmentBiomarkers, TumorMicroRNAsBiomarkersExosomeGastric cancerH. pyloriMicroRNATherapeutic strategies

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.