Evidence map›Paper›PMID 41045348›Full record

ArticleInfection2026

Tuberculosis outbreak in a German daycare center.

Cornelia Feiterna-Sperling, Julia von Hake, Birgit Lala, Mirjam Völler, Lujin Zaidan-Braun, Luise Martin, Annette Günther, Dinah von Schöning, Renate Krüger

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In one paragraph

Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cornelia Feiterna-SperlingDepartment of Pediatric Respiratory Medicine, Immunology, and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Julia von HakeHealth Department, Bezirksamt Lichtenberg von Berlin, Berlin, Germany.
Birgit LalaDepartment of Pediatric Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Mirjam VöllerDepartment of Pediatric Respiratory Medicine, Immunology, and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Lujin Zaidan-BraunHealth Department, Bezirksamt Lichtenberg von Berlin, Berlin, Germany.
Luise MartinDepartment of Pediatric Respiratory Medicine, Immunology, and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Annette GüntherClinic for Pediatrics and Adolescent Medicine, Helios Klinikum Emil von Behring, Berlin, Germany.
Dinah von SchöningDepartment of Microbiology and Hygiene, Labor Berlin - Charité Vivantes GmbH, Berlin, Germany.
Renate KrügerDepartment of Pediatric Respiratory Medicine, Immunology, and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. r.krueger@charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeYoung children who are exposed to people with infectious tuberculosis (TB) have an increased risk of developing TB disease following infection. The risk of infection and disease progression can be minimized by prompt identification of TB-exposed individuals and initiation of prophylactic or preventive treatment.

methodsWe report on a TB outbreak in a daycare center in Berlin, Germany following a delayed diagnosis of cavitary pulmonary TB in a childhood educator. We describe contact investigation, diagnostic, prophylactic, preventive and therapeutic measures in 62 TB-exposed children (median age 3.9 years), including 30 with prolonged TB exposure.

resultsThe initial examination took place 5-16 days after the index patient was diagnosed with TB. Ten of the 30 children with intensive contact became infected, six (median age 2.7 years) developed pulmonary TB. Three of these children had a concurrent influenza infection, which may have contributed to disease progression. No child without prolonged exposure to the index patient developed disease.

conclusionEarly diagnosis of TB in adult patients, especially those with persistent cough, is crucial to prevent TB in vulnerable infants. Close collaboration between public health departments and specialized facilities is essential for the effective control of TB outbreaks.

Indexed as

Child Day Care CentersDisease OutbreaksTuberculosisTuberculosis, PulmonaryBerlinChildChild, PreschoolContact TracingFemaleGermanyHumansInfantMaleContact investigationDaycare centerIndex caseInterferon-gamma release assayTuberculin skin testTuberculosis outbreak

Identifiers

PMID41045348
PMCPMC12864228

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.