Evidence map›Paper›PMID 41045334›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Health utility book: A systematic review and meta-analysis of health utilities in gastric cancer.

Shant Torkom Yeretzian, Brittany Humphries, Meixuan Li, Chiranjeev Sanyal, Gaurav Talwar, Michael Xu, Peijing Yan, Frances Simbulan, Zhiyuan Chen, Pei Wang and 8 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shant Torkom YeretzianInstitute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.
Brittany HumphriesDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Meixuan LiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Chiranjeev SanyalCollege of Pharmacy, Dalhousie University, Halifax, NS, Canada.
Gaurav TalwarDepartment of General Surgery, McMaster University, Hamilton, ON, Canada.
Michael XuDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Peijing YanDepartment of Science and Technology, Clinical Research Centre, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Frances SimbulanInstitute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.
Zhiyuan ChenDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Pei WangSchool of Public Health, Fudan University, Shanghai, China.
Ting ZhouSchool of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China.
Veena ManjaDepartment of Medicine, Division of Cardiology, UC Davis, Sacramento, CA, USA.
Xuejing JinCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China.
Yuan SunDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Preston TseDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Michael J ZorattiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Shitong XieDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Feng XieDepartment of Health Research Methods, Evidence, and Impact, McMaster University, CRL 223, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. fengxie@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe treatment landscape in gastric cancer has changed drastically over the last 15 years with surgical advancements and the introduction of new therapeutic agents and combinations. Despite the potential for improved survival, these new interventions can impact health-related quality of life (HRQoL). Our objective was to identify and synthesize health utility data for gastric cancer patients as part of the Health Utility Book (HUB) project.

methodsWe searched MEDLINE, EMBASE, EconLit, and CINAHL from inception to March 2023 for original studies that reported health utility data for gastric cancer. Records were screened independently and in duplicate by two reviewers. Data on study design, patient characteristics, and health utilities were extracted using a standardized form. A random effects meta-analysis was conducted to synthesize health utilities by cancer stage. Heterogeneity was evaluated using the I

results600 health utilities from 3,405 respondents were identified across 19 studies. All studies were published between 2018 and 2022 and most were conducted in Asia (n = 12, 63.2%). The EQ-5D was the most common method of preference elicitation (n = 17, 89.5%), and health utilities ranged from 0.298 (SD 0.088) to 0.920 (SD 0.130). Mean health utilities from random effects models were 0.82 (95% Confidence Interval [CI] 0.76-0.88), 0.76 (95% CI 0.68-0.85), and 0.67 (95% CI 0.46-0.87) for early stage, advanced stage, and metastatic gastric cancer, respectively.

conclusionThis systematic review provides a reference set of health utilities for gastric cancer, which can help understand HRQoL and facilitate the retrieval and selection of health utilities for economic evaluations.

Indexed as

Quality of LifeStomach NeoplasmsHumansQuality-Adjusted Life YearsEQ-5DGastric cancerHealth-related quality of lifeHealth utilityMeta-analysisSystematic review

Identifiers

PMID41045334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.