ArticleJournal of veterinary science2025
Integration of locking screw fixation into 3D-printed patient-specific porous titanium implants enhances osseointegration: an
Article in Journal of veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Modular Revision of a Failed Patient-Specific 3D-Printed Scapulo-Humeral Endoprosthesis in a Dog with Proximal Humeral Osteosarcoma: First Clinical Communication.Animals : an open access journal from MDPI · 2026Article
- Trochlear ridge reconstruction using a patient-specific three-dimensionally printed titanium implant in a dog with severe unilateral trochlear deformity and complex femoral deformity: a long-term follow-up case report.The Journal of veterinary medical science · 2026Article
- Patient-Specific Lattice Implants for Segmental Femoral and Tibial Reconstruction (Part 2): CT-Based Personalization, Design Workflows and Validation-A Review.Biomimetics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
importanceThree-dimensional (3D) printing enables fabrication of patient-specific implants (PSIs) tailored to complex bone defects. Although locking screw fixation offers mechanical advantages in conventional plating, its integration into 3D-PSIs is technically challenging and has not been evaluated for biological outcomes.
objectiveThis study aimed to assess whether locking screw fixation enhances osseointegration compared to nonlocking fixation when directly integrated into 3D-printed porous titanium implants.
methodsSegmental femoral defects (20 mm) were created in ten adult rabbits, and customized porous Ti6Al4V implants were designed based on preoperative computed tomography (CT) scans. The implants incorporated threaded holes replicating the ARIX locking system and were fabricated via selective laser melting. Animals were randomly assigned to locking (n = 5) or nonlocking (n = 5) screw fixation groups. After 12 weeks, implant osseointegration was evaluated using radiography, micro-CT, and histological analyses.
resultsAll implants remained stable without failure. Micro-CT revealed significantly higher bone volume fraction in the locking group (27.8% ± 3.7%) than the nonlocking group (23.8% ± 1.7%; CONCLUSIONS AND RELEVANCE: This study demonstrates that integrating locking screw fixation into 3D-printed porous titanium PSIs enhances osseointegration by improving primary stability. These findings suggest that locking fixation in PSI designs may improve outcomes for load-bearing bone defect reconstructions in veterinary and potentially human applications.
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Registered trials
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