ArticleSleep2026
Respiratory-related leg movement as a predictor of mortality: the Osteoporotic Fractures in Men Sleep Study.
Article in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The future of periodic limb movements during sleep: beyond the periodic limb movement index.Sleep · 2026Article
- When the legs speak for the lungs.Sleep · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
STUDY
objectivesRespiratory event-related leg movements (RRLMs) in obstructive sleep apnea may reflect event severity and predict adverse outcomes. This study examines the association between RRLM frequency and mortality.
methodsA sample of 571 men (median [IQR] age: 76.0 [72.0-81.0] years; BMI: 28.0 [25.0-30.0] kg/m2) with an apnea-hypopnea index (AHI, ≥3 per cent desaturation) ≥10 events/h was selected based on available incident data and annotations of RRLMs, from the Osteoporotic Fractures in Men Studies . RRLMs were scored if they occurred within ±5 s of respiratory event termination lasting 0.5-10 s; the average number of RRLMs per hour of sleep respiratory-related leg movement index (RRLMI) was measured. For comparison, the number of periodic leg movements of sleep (PLMS) per hour of sleep (PLMI) was also quantified. Cox regression models estimated the adjusted hazard ratios (aHR) for mortality per SD increase in RRLMI and PLMI. Secondary analyses assessed the relationship between RRLM duration (i.e. a measure of RRLM strength) and measures of event severity (i.e. desaturation area, arousal, heart rate response, and event duration).
resultsThere were 287 all-cause deaths during 11.4 [6.9;12.5] years of follow-up. RRLMI and PLMI were 6.0 [3.4;9.3] and 22.0 [2.0;54.0] events/h, respectively. In an adjusted model, every 1SD increase in RRLMI was associated with all-cause mortality (aHR: 1.17 [95% CI: 1.01-1.34], p-value = .03). In contrast, PLMI was not associated with mortality (aHR: 1.04 [95% CI: 0.92-1.17], p-value = .5). Furthermore, RRLM duration was linked to measures of event severity.
conclusionsIn a sample of older men with obstructive sleep apnea, RRLMI was independently associated with all-cause mortality, whereas PLMI was not, though confirmatory studies are needed.
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