Evidence map›Paper›PMID 41045134›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2026

Bone microstructural and strength changes over 1 year in children with osteogenesis imperfecta are comparable to age- and sex-matched healthy controls.

Seyedmahdi Hosseinitabatabaei, Samantha McCluskey, Carolyn Denton, Elizabeth A Zimmermann, Francis H Glorieux, Fredrick Charbonneau, Frank Rauch, Bettina M Willie

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seyedmahdi HosseinitabatabaeiResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.ORCID 0000-0002-5638-976X
Samantha McCluskeyResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.
Carolyn DentonResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.
Elizabeth A ZimmermannResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.ORCID 0000-0001-9927-3372
Francis H GlorieuxResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.ORCID 0000-0001-6616-3484
Fredrick CharbonneauResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.
Frank RauchResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.
Bettina M WillieResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC H4A 0A9, Canada.ORCID 0000-0003-2907-3580

Funding

FRQS Programme de bourses de chercheurMereo BioPharma, Shriners Hospitals for Children
6 · The paper itself

Abstract

introductionOsteogenesis imperfecta (OI) is characterized by bone fragility with frequent fractures, especially in children. Some studies have used peripheral-QCT (pQCT) to examine bone density in children with OI and one cross-sectional study used HR-pQCT in 9 children with OI. MATERIALS AND

methodsWe compared bone density, microstructure, and strength changes over 1 yr at the metaphysis and diaphysis of the radius and tibia, as well as lumbar spine (LS) bone mass and area, in 20 children with OI under bisphosphonate treatment and 20 age- and sex-matched controls. For the double-stack metaphyseal scans, we developed an algorithm to correct stack misalignment. For the LS, we used DXA.

resultsAt the tibial metaphysis, children with OI had lower baseline total and trabecular volumetric BMD (vBMD), trabecular and cortical microstructure, and strength. At the radial metaphysis, baseline trabecular microstructure and strength were lower in children with OI. At the tibial and radial diaphysis, children with OI had lower bone area and strength. At the tibial and radial metaphysis, 1-yr increases in most measurements were similar for both groups. Cortical vBMD and trabecular separation (radius) only increased in the OI group. Trabecular vBMD, volume fraction (tibia), number (tibia), and total vBMD (radius) only increased in the control group. At the tibia and radius diaphysis, cortical vBMD increased in the OI group. Tibial Ct.Po decreased in children with OI. At the LS, the OI group had lower bone mass, density, and area, but similar longitudinal changes. DISCUSSION: In summary, baseline trabecular bone density, trabecular and cortical microstructure, and strength were lower in metaphyseal regions of children with OI. At diaphysis, children with OI had lower bone area and strength. While longitudinal changes over 1 yr were generally comparable, certain outcomes demonstrated differences. These data are essential for powering future clinical trials.

Indexed as

Bone and BonesOsteogenesis ImperfectaAbsorptiometry, PhotonAdolescentBone DensityCase-Control StudiesChildChild, PreschoolFemaleHumansMaleRadiusTibiaTomography, X-Ray Computedbone microstructurebone strengthlongitudinal HR-pQCTosteogenesis imperfectapediatrics

Identifiers

PMID41045134
PMCPMC13229919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.