ReviewImmunology2025
Antibody Polyreactivity: A Challenger of Immune Paradigms.
Review in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Whole-cell surface-display system in attenuated Salmonella Enteritidis for slide microagglutination-based antibody detection.Microbial cell factories · 2026Article
- Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections.Cell · 2026Article
- Mechanistic insight into the oxidative degradation of monoclonal antibodies: relevance to developability and the design of stable pharmaceutical formulations.Biochemical Society transactions · 2026Review
- Monoclonal Antibodies and Derivatives: Therapeutic Tools for Cancer.Oncology research · 2026Review
- Antibody Polyreactivity: A Challenger of Immune Paradigms.Immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity. Here, we discuss the diverse molecular mechanisms underlying polyreactivity, including conformational dynamics, sequence- and structural characteristics of antigen-binding sites. The importance of polyreactive antibodies in immune defence and immune homeostasis is highlighted as well as their potential pathological consequences. Polyreactivity is seen as a continuum rather than a discrete property so that ultimately all antibodies possess some degree of polyreactivity. The challenges in defining antibody specificity are examined, and a shift towards quantitative thinking in antibody research is suggested. This would foster the adoption of novel methodologies to study complex antibody-antigen interactions at a systems level. Finally, the deeper understanding of polyreactivity's potential implications for the current antibody paradigm is critically evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.