ArticleBiomaterials science2025
A tissue-engineered endothelial cell - smooth muscle cell arteriole-like model.
Article in Biomaterials science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics.Scientific reports · 2026Article
- Spontaneous Helical Alignment of Smooth Muscle Cells to Form a Medial Layer for Engineered Microvasculature.Advanced healthcare materials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Arterioles are small arteries that play a pivotal role in regulating blood flow and pressure. Co-culture of smooth muscle cells (SMCs) and endothelial cells (ECs) in a collagen fiber matrix with the correct spatial organization has been challenging. Here, we report a 3D tissue-engineered arteriole model (∼150 μm in diameter) with co-cultured confluent monolayers of SMCs and ECs. We demonstrate the structural integrity and barrier function of the model with high resolution microscopy and permeability measurements. The arteriole model recapitulates physiological contraction and dilation under pulsatile flow. In addition, perfusion with an inflammatory cytokine induces increased adhesion of immune cells on the endothelium. Together, this model provides a novel platform for studying the structure and function of human arterioles, paving the way for drug development targeting arteriole disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.