Evidence map›Paper›PMID 41044892›Full record

ArticleBirth (Berkeley, Calif.)2026

Pathways to Birth Trauma: Prenatal PTSD as a Mediator Between Adverse Childhood Experiences and Childbirth-Related PTSD Symptoms.

Samantha Addante, Elizabeth Hinckley, Gina Erato Garza, Kristin Fields Creech, Ashley Quigley, Karina M Shreffler, Lucia Ciciolla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth (Berkeley, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha AddanteDepartment of Psychiatry & Behavioral Science, RUSH University Medical Center, Chicago, Illinois, USA.ORCID 0009-0000-0213-9936
Elizabeth HinckleyDepartment of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.
Gina Erato GarzaWarren Alpert Medical School of Brown University & Rhode Island, Providence, Rhode Island, USA.
Kristin Fields CreechDepartment of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.
Ashley QuigleyDepartment of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.
Karina M ShrefflerFran and Earl Ziegler College of Nursing, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0003-0475-5817
Lucia CiciollaDepartment of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.

Funding

The Impact of Maternal Adversity and Attachment Security on Infant Stress Reactivity: Prenatal Epigenetic PathwaysP20GM109097 · NIGMS · OSU CENTER FOR HEALTH SCIENCES · PI Dian Yu · 2016 to 2026
$22.8M
J. NRSA Training CoreTL1TR002388 · NCATS · UNIVERSITY OF CHICAGO · PI ALI KESHAVARZIAN, Sonia Kupfer · 2017 to 2026
$6.7M
Training in Child/Adolescent Biobehavioral HIV ResearchT32MH078788 · NIMH · RHODE ISLAND HOSPITAL · PI LARRY K BROWN · 2007 to 2026
$6.2M
Center for Integrated Research on Child Adversity P20GM109097National Research Service Award 5TL1TR002388NCATS NIH HHS TL1 TR002388NICHD NIH HHS L30 HD119793NIGMS NIH HHS P20 GM109097NIMH NIH HHS T32 MH078788
6 · The paper itself

Abstract

backgroundExtensive research highlights the risk of PTSD following traumatic childbirth. However, PTSD during pregnancy-whether preexisting or emerging prenatally-receives far less attention despite its associated harmful effects on maternal and infant well-being. To fill this gap, the current study examines predictors of childbirth-related PTSD symptoms, including maternal ACEs and prenatal PTSD symptoms in 91 mothers from a diverse community sample (47% particpants of c) within the United States.

methodsParticipants completed questionnaires on ACEs and PTSD symptoms during their third trimester of pregnancy and childbirth-related PTSD symptoms at 6-weeks postpartum. The current study used a path analysis model to examine the mediating effects of prenatal PTSD on the relationship between ACEs and childbirth-related PTSD symptoms at 6-weeks postpartum.

resultsFindings indicated that ACEs have implications for childbirth-related PTSD symptoms at 6-weeks postpartum with a significant indirect effect through prenatal PTSD, standardized indirect effect = 0.20, 95% CI = [0.02, 0.36], p = 0.03.

conclusionScreening for childhood adversity during pregnancy may have dual benefits for prenatal and postpartum health, such that screening can help identify women at risk for prenatal PTSD as well as those at risk for later childbirth-related trauma symptoms who may benefit from trauma-informed targeted prevention and intervention efforts.

Indexed as

Adverse Childhood ExperiencesMothersParturitionStress Disorders, Post-TraumaticAdultFemaleHumansPostpartum PeriodPregnancyRisk FactorsSurveys and QuestionnairesUnited StatesYoung Adultadversitybirth traumapostpartumpregnancyPTSD

Identifiers

PMID41044892
PMCPMC12978674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.