ArticleAlcohol, clinical & experimental research2025
Interactions between the bone morphogenetic protein and the planar cell polarity pathways lead to distinctive ethanol-induced facial defects.
Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Interactions between the bone morphogenetic protein and the planar cell polarity pathways lead to distinctive ethanol-induced facial defects.Alcohol, clinical & experimental research · 2025Article
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Abstract
backgroundFetal alcohol spectrum disorders (FASD) describe a spectrum of ethanol-induced developmental defects. Ethanol susceptibility is modulated by genetics, but the underlying mechanisms remain poorly understood. In all vertebrates, complex cellular events give rise to the body plan, including gastrulation and morphogenesis of the endoderm and cranial neural crest (CNC-gives rise to the facial skeleton). These events are crucial for establishing complex signaling interactions that drive embryo development, including the formation of the facial skeleton. In zebrafish, gastrulation occurs between 6 and 10 h postfertilization (hpf), while endoderm/CNC morphogenesis occurs between 10 and 24 hpf. In previous work, planar cell polarity (PCP) mutants are ethanol-sensitive from 6 to 24 hpf (covering both gastrulation and endoderm/CNC morphogenesis), exhibiting multiple defects in the forming head. This raises the question of whether ethanol during both these time windows drives PCP-ethanol defects. We hypothesize that PCP mutants are ethanol-sensitive from 10 to 24 hpf, after gastrulation. We also hypothesize that bone morphogenetic protein (BMP) signaling (ethanol-sensitive 10-18 hpf) interacts with and sensitizes the PCP pathway to ethanol.
methodsWe treated PCP/BMP mutants with ethanol over various time windows between 6 and 30 hpf and combined morphometric and linear measurements to examine facial development.
resultsWe show that PCP mutants are largely ethanol-sensitive from 10 to 24 hpf. We also show that BMP mutants sensitize PCP mutants to ethanol and lead to novel ethanol-independent midline craniofacial defects. Our results suggest that the ethanol-sensitive role of the PCP pathway occurs after gastrulation, during endoderm/CNC morphogenesis, and that the PCP and BMP pathways genetically interact during the morphogenetic events.
conclusionsUltimately, our work builds on a mechanistic paradigm of ethanol-induced birth defects we have been developing, connecting the conceptual framework with concrete cellular events that could be ethanol-sensitive beyond facial development.
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