Evidence map›Paper›PMID 41044864›Full record

ReviewDevelopmental medicine and child neurology2026

Modeling cerebral palsy in animals.

Katharina A Quinlan, Emily J Reedich, Elvia Mena Avila, Brendan C Moline, Landon T Genry, Megan R Detloff, Benjamin R Katholi, Deborah Gaebler-Spira, Bhooma R Aravamuthan

Abstract readReview
In one paragraph

Review in Developmental medicine and child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katharina A QuinlanUniversity of Rhode Island, College of Pharmacy, Kingston, RI, USA.ORCID 0000-0002-6177-4849
Emily J ReedichUniversity of Rhode Island, College of Pharmacy, Kingston, RI, USA.
Elvia Mena AvilaUniversity of Rhode Island, College of Pharmacy, Kingston, RI, USA.
Brendan C MolineUniversity of Rhode Island, College of Pharmacy, Kingston, RI, USA.
Landon T GenryUniversity of Rhode Island, College of Pharmacy, Kingston, RI, USA.
Megan R DetloffDrexel University College of Medicine, Philadelphia, PA, USA.
Benjamin R KatholiNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.
Deborah Gaebler-SpiraNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.
Bhooma R AravamuthanWashington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-0205-2149

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI KOGUT, STEPHEN J · 2016 to 2025
$45.0M
Validation of Prenatal Rabbit Hypoxia Ischemia as a Model of Cerebral Palsy-induced PainRF1NS135580 · NINDS · UNIVERSITY OF RHODE ISLAND · PI MEGAN R DETLOFF, Katharina Ann Quinlan · 2023 to 2026
$4.6M
Impairment of Spinal Development in Cerebral PalsyR01NS104436 · NINDS · UNIVERSITY OF RHODE ISLAND · PI Katharina Ann Quinlan · 2017 to 2026
$4.3M
Validation of Targeting Macrophage-Mediated Events in the DRG to Alleviate Chronic Spinal Cord Injury PainR01NS097880 · NINDS · DREXEL UNIVERSITY · PI MEGAN R DETLOFF · 2017 to 2026
$4.0M
Serotonin Based Therapeutics in Cerebral PalsyR01NS132728 · NINDS · UNIVERSITY OF RHODE ISLAND · PI Katharina Ann Quinlan · 2023 to 2026
$2.5M
Modulation of striatal cholinergic interneuron activity to prevent dystonic cerebral palsyK08NS117850 · NINDS · WASHINGTON UNIVERSITY · PI ARAVAMUTHAN, BHOOMA · 2021 to 2025
$927k
Craig H. Neilsen Foundation Pilot Grant #1001637NIGMS NIH HHS U54 GM115677NINDS NIH HHS 1K08NS117850-01A1NINDS NIH HHS K08 NS117850NINDS NIH HHS R01 NS097880NINDS NIH HHS R01NS097880NINDS NIH HHS R01 NS104436NINDS NIH HHS R01NS104436NINDS NIH HHS R01 NS132728NINDS NIH HHS R01NS132728NINDS NIH HHS RF1 NS135580NINDS NIH HHS RF1NS135580University of Rhode Island College of Pharmacy Seed Grant, University of Rhode Island Proposal Development Grant, and National Institute of General Medical Sciences U54GM115677
6 · The paper itself

Abstract

Advancements in the treatment of cerebral palsy depend on animal research. Yet, most animal models have not been fully evaluated for spasticity and dystonia using clinically relevant measures of altered tone or movement patterns, which form the basis for diagnosing people with the condition. Sensory differences and pain are almost never studied in animal models. Complicating factors include the diversity of animals and injuries used to model the condition, the diversity of outcomes after acquired injury, and translating clinical measures into reliable and repeatable measurements tailored to animals, ideally using common data elements. We summarize preclinical models based on acquired injury to the nervous system in cerebral palsy research over the years and provide a comparison of developmental time courses for common laboratory animals. We encourage researchers to coalesce on consistent, reliable measurements for assessing both sensory and motor systems to ensure that animal models reflect meaningful aspects of the condition.

Indexed as

Cerebral PalsyDisease Models, AnimalAnimalsHumans

Identifiers

PMID41044864
PMCPMC12766561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.