Evidence map›Paper›PMID 41044854›Full record

ArticleCancer science2025

Deletion of the Mis12C-Binding Domain of CENP-C Promotes Chromosomal Aneuploidy in Cutaneous Squamous Cell Carcinoma.

Megumi Saito, Kazuhiro Okumura, Yurika Tokunaga, Sora Tanaka, Keisuke Otoyama, Yoshinori Hasegawa, Masatoshi Hara, Masakazu Hashimoto, Toshihiko Fujimori, Tatsuo Fukagawa and 1 more

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Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Megumi SaitoDivision of Experimental Animal Research, Cancer Genome Center, Chiba Cancer Center Research Institute, Chiba, Japan.
Kazuhiro OkumuraDivision of Experimental Animal Research, Cancer Genome Center, Chiba Cancer Center Research Institute, Chiba, Japan.
Yurika TokunagaDivision of Experimental Animal Research, Cancer Genome Center, Chiba Cancer Center Research Institute, Chiba, Japan.
Sora TanakaDivision of Experimental Animal Research, Cancer Genome Center, Chiba Cancer Center Research Institute, Chiba, Japan.
Keisuke OtoyamaDivision of Experimental Animal Research, Cancer Genome Center, Chiba Cancer Center Research Institute, Chiba, Japan.
Yoshinori HasegawaDepartment of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan.
Masatoshi HaraDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Masakazu HashimotoDepartment of Cell Science, Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Toshihiko FujimoriDivision of Embryology, National Institute for Basic Biology, Aichi, Japan.
Tatsuo FukagawaGraduate School of Frontier Biosciences, The University of Osaka, Osaka, Japan.
Yuichi WakabayashiDivision of Experimental Animal Research, Cancer Genome Center, Chiba Cancer Center Research Institute, Chiba, Japan.ORCID https://orcid.org/0000-0002-8861-2954

Funding

Japan Society for the Promotion of Science 22H0040
6 · The paper itself

Abstract

CENP-C, an essential component of the kinetochore, connects centromeric chromatin to the outer kinetochore, and thereby ensures accurate chromosome segregation. Although deletion of the Mis12-binding domain (M12BD) of CENP-C does not cause developmental disorders in mice, it promotes malignant tumor progression in the two-stage DMBA/TPA-induced skin carcinogenesis model. In this study, we have demonstrated that M12BD deletion of CENP-C enhances proliferation and then promotes abnormal differentiation in DMBA/TPA-induced carcinomas in mice. To elucidate the underlying molecular mechanisms, we performed RNA sequencing and found the dysregulated expression of keratinization-related genes. Intriguingly, elevated chromosomal aneuploidy was detectable in mice with the M12BD deletion of CENP-C. Among the aneuploidies, trisomies of chromosomes 6 and 10 took place at the highest frequency. These specific chromosomal gains were accompanied by upregulation of genes involved in immune and inflammatory responses. Together, our present findings strongly suggest that M12BD of CENP-C plays a critical role in the regulation of epithelial differentiation during tumor development in mice.

Indexed as

AneuploidyCarcinoma, Squamous CellChromosomal Proteins, Non-HistoneSkin Neoplasms9,10-Dimethyl-1,2-benzanthraceneAnimalsCell DifferentiationCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMice9,10-Dimethyl-1,2-benzanthracenecentromere protein CChromosomal Proteins, Non-HistoneaneuploidyCENPkeratinizationmouse modelsquamous cell carcinoma

Identifiers

PMID41044854
PMCPMC12666478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.