Evidence map›Paper›PMID 41044833›Full record

ArticleAllergy, asthma & immunology research2025

Characterizing Systemic Reactions During Subcutaneous Immunotherapy for House Dust Mite Allergies in China: Insights From a Cluster Analysis Study.

Qingxiu Xu, Jinling Liu, Xiang Dong, Lisha Li, Hao Chen, Yin Wang, Hongting Zhang, Juan Meng, Kai Guan, Pascal Demoly and 1 more

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In one paragraph

Article in Allergy, asthma & immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Qingxiu Xu *Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0000-9950-891X
Jinling Liu *Department of Pulmonary Medicine, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xiang Dong *Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0002-5241-4307
Lisha LiDepartment of Allergy, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0002-1171-1858
Hao ChenDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0001-6959-5450
Yin WangDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hongting ZhangDepartment of Otolaryngology - Head & Neck Surgery/Allergy Center of West China Hospital, Sichuan University, Chengdu, China.
Juan MengDepartment of Otolaryngology - Head & Neck Surgery/Allergy Center of West China Hospital, Sichuan University, Chengdu, China. mjmelinda@163.com.ORCID https://orcid.org/0009-0008-0957-9238
Kai GuanDepartment of Allergy, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. dr_guankai@126.com.ORCID https://orcid.org/0000-0003-0850-5874
Pascal DemolyAllergy Unit, Pulmonology Department, Hôpital Arnaud de Villeneuve and IDESP, University of Montpellier-Inserm, Montpellier, France. pascal.demoly@inserm.fr.ORCID https://orcid.org/0000-0001-7827-7964
Rongfei ZhuDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0003-2103-3381

Funding

National Key R&D Program of China 2023YFC2507900
6 · The paper itself

Abstract

purposeSubcutaneous immunotherapy (SCIT) can trigger systemic reactions (SRs) that pose potential life-threatening risks. To date, no cluster analysis has been conducted to delineate sub-phenotypes of SRs. This study aims to identify and characterize diverse SR phenotypes during SCIT for house dust mite (HDM) allergies in China.

methodsThis large retrospective real-world study enrolled patients diagnosed with HDM-sensitized allergic rhinitis (AR) and/or asthma who underwent SCIT (Alutard SQ; ALK) between February 2013 and July 2024 at five allergy centers in China. Data on demographic profiles and SRs were collected, followed by a cluster analysis among SR patients.

resultsA total of 3,126 patients received 107,588 injections, with SRs observed in 354 patients (11.32%) and 1,056 injections (0.98%). A higher incidence of SRs was noted in younger patients (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.88-0.92;

conclusionsAsthma, disease duration, high sensitization, and polysensitization emerge as independent risk factors for SRs. Our cluster analysis delineates distinct clinical phenotypes of SRs, offering tailored interventions for the personalized management of patients experiencing SRs.

Indexed as

allergic rhinitisasthmacluster analysisHouse dust mitesubcutaneous immunotherapysystemic reaction

Identifiers

PMID41044833
PMCPMC12511792

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