Evidence map›Paper›PMID 41044814›Full record

ArticleACS biomaterials science & engineering2025

Development of Dendritic Cell Membrane-Coated Nanoparticles for Antigen-Specific T-Cell Engagement.

Sao Puth, Shruti Sunil Jadhav, Ali Zareein, Jimmy Blauser-Wilson, Mina Mahmoudi, Ruben Rojas Betanzos, Bayonel Ventura, Andrea M Sprague-Getsy, Xiaoran Hu, James L Hougland and 1 more

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sao PuthDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.
Shruti Sunil JadhavDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.
Ali ZareeinDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.
Jimmy Blauser-WilsonDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.
Mina MahmoudiDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.
Ruben Rojas BetanzosDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.
Bayonel VenturaDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.
Andrea M Sprague-GetsyThe BioInspired Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13210, United States.
Xiaoran HuThe BioInspired Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13210, United States.ORCID 0000-0001-7598-4516
James L HouglandThe BioInspired Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13210, United States.ORCID 0000-0003-0444-1017
Yaoying WuDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13210, United States.ORCID 0000-0003-0570-2493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cell (DC) membrane-coated nanoparticles (DCmPs) hold significant potential for antigen-specific therapies. DCmPs carry key DC membrane proteins that facilitate DC-T cell interaction, such as the major histocompatibility complex (MHC), costimulatory CD80/86, and adhesive molecules ICAM-1. However, our current understanding of the impact of the coating processes and the composition of the final products is very limited, significantly hindering the development of DCmP-based therapy. Here, using DC2.4 cell membrane proteins and poly(lactic-

Indexed as

Cell MembraneDendritic CellsNanoparticlesT-LymphocytesHumansMembrane ProteinsPolylactic Acid-Polyglycolic Acid CopolymerMembrane ProteinsPolylactic Acid-Polyglycolic Acid Copolymerantigen presentationantigen-specific therapyDCmPextrusionmembrane-coated nanoparticlessonication

Identifiers

PMID41044814
PMCPMC12606551

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.