Evidence map›Paper›PMID 41044810›Full record

ArticleAnnals of dermatology2025

Clinical Validation of the Updated Korean Atopic Dermatitis Diagnostic Criteria in a Hospital Setting in South Korea.

Seungah Yoo, Jaeeun Song, Jung Eun Kim, Ji Hae Lee, Hyun Ji Lee, Kyung Ho Lee, Yu Ri Woo, Young Bok Lee, Ji Hyun Lee, Sang Hyun Cho

Abstract read
In one paragraph

Article in Annals of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Seungah YooDepartment of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-5794-6046
Jaeeun SongUniversity of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2053-7131
Jung Eun KimDepartment of Dermatology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-1670-0995
Ji Hae LeeDepartment of Dermatology, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.ORCID https://orcid.org/0000-0002-5132-1627
Hyun Ji LeeDepartment of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-8643-8462
Kyung Ho LeeDepartment of Dermatology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.ORCID https://orcid.org/0000-0002-0108-3376
Yu Ri WooDepartment of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.ORCID https://orcid.org/0000-0003-2903-9534
Young Bok LeeDepartment of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.ORCID https://orcid.org/0000-0002-8642-2479
Ji Hyun LeeDepartment of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. yiji1@hanmail.net.ORCID https://orcid.org/0000-0002-3671-502X
Sang Hyun ChoDepartment of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.ORCID https://orcid.org/0000-0001-8289-1190

Funding

Ministry of Education of the Republic of KoreaNational Research Foundation of Korea RS-2025-00556282
6 · The paper itself

Abstract

backgroundAtopic dermatitis (AD) is a common chronic inflammatory skin disease whose diagnosis relies on clinical presentation and history due to the absence of definitive diagnostic tests or biomarkers. The Korean Atopic Dermatitis Association (KADA) recently updated its diagnostic criteria to enhance accuracy and applicability.

objectiveThis study validates the updated KADA criteria by assessing their diagnostic performance in a clinical setting and comparing them with the previous KADA and Japanese Dermatological Association (JDA) criteria.

methodsA multicenter, cross-sectional study was conducted with 231 AD patients and 81 non-AD controls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden's index, and error rates for the criteria and individual clinical features included were analyzed.

resultsThe updated KADA criteria demonstrated the highest sensitivity (63.20%) compared to the previous KADA (61.04%) and JDA criteria (47.62%), enabling better identification of a broader range of AD phenotypes. While its specificity (82.72%) was slightly lower than that of the previous KADA (88.89%) and JDA criteria (95.06%), the updated criteria maintained a strong PPV of 91.01% and a comparable NPV of 44.10%. The Youden's index for the updated criteria was 0.459, indicating a balanced trade-off between sensitivity and specificity, and the error rate was the lowest (31.41%), underscoring its enhanced overall diagnostic accuracy.

conclusionThe updated KADA criteria provide a practical and intuitive diagnostic tool, effectively addressing the limitations of previous criteria and improving the efficient and comprehensive diagnosis of AD, especially in those with diverse presentations.

Indexed as

Atopic dermatitisDiagnosisSensitivity and specificityValidation study

Identifiers

PMID41044810
PMCPMC12505368

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