ArticleActa neuropathologica communications2025
The mGluR5 agonist CHPG enhances human oligodendrocyte differentiation.
Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Article
- Transcriptional Heterogeneity Reveals a Synaptic Gene Program in Developing and Adult Human Oligodendrocyte Precursor Cells.bioRxiv : the preprint server for biology · 2026Article
- Triple antibody-associated autoimmune encephalitis overlap: a case report of co-existing MOG-IgG, anti-NMDAR, and anti-mGluR5 positivity.Frontiers in immunology · 2026Article
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Abstract
Previous studies in adult mice indicate that the mGluR5 agonist 2-chloro-5-hydroxyphenyl glycine (CHPG), reduces cuprizone-elicited losses in myelin. This effect is partly mediated by CHPG binding to mGluR5 receptors on reactive astrocytes, triggering the release of brain derived neurotrophic factor (BDNF), which results in an increase in myelin. However, it remains unclear whether CHPG has similar beneficial effects on human oligodendrocytes. To address this issue, we examined effects of CHPG using both cultured human induced pluripotent stem cell (hiPSC)-derived oligodendrocytes and primary human fetal oligodendrocytes. We show that CHPG increases the proportion of MBP
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