ArticleBMC veterinary research2025
Effect of heat stress on some serum and reproductive parameters of Holstein dairy cows in Egypt: potential biomarkers.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Distinct physiological and immunoendocrine responses in indigenous dairy heifers during cold-humid (THI-50) vs. hot dry (THI-76) climatic conditions.Tropical animal health and production · 2026Article
- Six things to know about how heat stress compromises fertility of the cow (and probably other mammals as well).The Journal of reproduction and development · 2026Review
- Effect of heat stress on some serum and reproductive parameters of Holstein dairy cows in Egypt: potential biomarkers.BMC veterinary research · 2025Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHeat stress (HS) is one of the major factors that can negatively affect both reproduction and milk production of dairy cows. Thus, the HS results in economic losses in the dairy industry. The objective of the present study was to assess reliable biomarkers related to the effect of HS on reproduction in dairy cows under Egyptian conditions. Meteorological data were collected to calculate the Temperature-Humidity Index (THI). Reproductive data and daily milk yield (MY) in summer and winter were collected. At the time of AI, blood samples were taken from 118 Holstein dairy cows, 25 in summer and 93 in winter, to measure the levels of heat shock protein 70 (HSP70), cortisol, interleukin-6 (IL-6), total antioxidant capacity (TAC), insulin-like growth factor-I (IGF-I), and glucose.
resultsThe reproductive parameters, services per conception were significantly increased in summer compared to those in winter, but the pregnancy rate was higher in winter compared with that in the summer. Also, MY was significantly declined in summer as compared with that in winter. Regarding the serum levels of HSP70, cortisol, and IL-6 were significantly increased during the summer than those in winter. However, the TAC and glucose were significantly decreased in summer than in winter. A positive correlation was found between THI and HSP70 (P < 0.05), cortisol (P < 0.01), and IL-6 (P < 0.01). At the same time, a negative correlation was recorded between THI and glucose (P < 0.01) and TAC (P < 0.001). However, there was no significant association between THI and IGF-I values. Regarding reproductive parameters, HSP70 was positively correlated with services per conception (P < 0.05) and negatively with pregnancy rate (P < 0.05). Cortisol showed a negative correlation with pregnancy rate (P < 0.001).
conclusionsThe present study provided that HSP70 and cortisol may be considered as potential biomarkers for HS affecting reproductive performance in dairy cows. Moreover, IL-6 and TAC could be used as additional biomarkers for evaluating the effect of HS on the immune system in dairy cows.
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