Evidence map›Paper›PMID 41044739›Full record

ArticleKorean circulation journal2025

Effectiveness and Safety of CENTUM™, an Everolimus-Eluting Stent, in Patients With Coronary Artery Disease: A Prospective Multi-Center Observational Study.

Wonjae Lee, Sun-Hwa Kim, Yisik Kim, Seung-Ho Hur, Seok Kyu Oh, Sang-Hyun Kim, Young Jin Choi, Namho Lee, Seung-Hwan Lee, Byung Ryul Cho and 4 more

Abstract read
In one paragraph

Article in Korean circulation journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wonjae LeeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6198-841X
Sun-Hwa KimDepartment of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-4673-6430
Yisik KimDepartment of Cardiology, Chonbuk National University Hospital, Jeonju, Korea.ORCID https://orcid.org/0000-0003-2458-5544
Seung-Ho HurDepartment of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.ORCID https://orcid.org/0000-0002-3895-1915
Seok Kyu OhDepartment of Cardiology, Wonkwang University Hospital, Iksan, Korea.ORCID https://orcid.org/0000-0001-7545-0143
Sang-Hyun KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8026-1582
Young Jin ChoiDepartment of Cardiology, Sejong General Hospital, Bucheon, Korea.ORCID https://orcid.org/0000-0002-7873-9396
Namho LeeDepartment of Cardiology, Hallym University, Kangnam Sacred Heart Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-7866-4614
Seung-Hwan LeeDepartment of Cardiology, Konkuk University College of Medicine, Chungju Hospital, Chungju, Korea.ORCID https://orcid.org/0000-0002-1186-0917
Byung Ryul ChoDepartment of Cardiology, Kangwon National University Hospital, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-2095-1121
Dong-Kie KimDepartment of Cardiology, Inje University Haeundae Paik Hospital, Busan, Korea.ORCID https://orcid.org/0000-0002-0268-5395
Sang Wook LimDepartment of Cardiology, CHA University CHA Medical Center, Seongnam, Korea.ORCID https://orcid.org/0000-0001-6916-4087
Tae-Jin YounDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-9957-4204
In-Ho ChaeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1644-2105

Funding

Osstem Cardiotec Co.
6 · The paper itself

Abstract

BACKGROUND AND

objectivesCENTUM is a biodegradable everolimus-eluting stent comprising a cobalt-chromium open-cell stent platform. In this prospective trial, we aimed to evaluate the effectiveness and safety of CENTUM™ in a clinical setting.

methodsA prospective, single-arm, multi-center observational registry was designed to assess the clinical outcomes after CENTUM implantation in all-comers who underwent percutaneous coronary intervention. The primary endpoint was a composite of cardiac death, nonfatal myocardial infarction, and target lesion revascularization at 12 months. The secondary endpoints included stent thrombosis and other clinical events (all-cause death, myocardial infarction, stroke, target vessel revascularization, and bleeding).

resultsTotal 490 patients were enrolled, and 451 completed the study. The mean age was 67.1 years, and 52.8% of the patients presented with acute coronary syndrome. The primary endpoint was observed in 1.11% of the patients. Definite/probable stent thrombosis was observed in 0.44% of the patients, whereas total clinical events recorded was 4.43%.

conclusionsCENTUM was effective and safe at 12 months in all patients who underwent percutaneous coronary intervention. Our findings support the broader application of CENTUM in patients with coronary artery disease.

trial registrationClinical Research Information Service Identifier: KCT0009898.

Indexed as

Coronary artery diseasePercutaneous coronary interventionStents

Identifiers

PMID41044739
PMCPMC12705251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.