ArticleBMC pediatrics2025
Clinical characteristics and prognosis of exchange transfusion in infants with severe pertussis.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Severe Pertussis During Early Infancy from a High-Altitude Region: Two Clinical Cases and Literature Review.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundTo explore the efficacy and clinical significance of exchange transfusion (ET) therapy in infants with severe pertussis, and provide a basis for the diagnosis and treatment of severe pertussis.
methods45 infants diagnosed with severe pertussis and receiving ET treatment in the intensive care unit of Hunan Children's Hospital from January 1, 2019 to June 30, 2024 were selected as the study subjects. According to the prognosis, they were divided into surviving group (n = 35) and mortality group (n = 10), and the clinical manifestations and biochemical indicators of the two groups were compared. The comparison between groups of count data was conducted using the chi square test. The t-test is used to compare between groups whose measurement data conforms to a normal distribution; The Mann Whitney U test is used to compare between groups that do not follow a normal distribution.
resultsThe mortality of 45 infants with severe pertussis who received ET treatment was 22.2% (10/45). The incidences of oliguria, bradycardia, and pleural effusion in the mortality group were higher than those in the surviving group, and the differences were statistically significant (P < 0.05). The white blood cells (WBC) and neutrophils (NE) in mortality group were significantly higher than those in surviving group before ET treatment. After 24 h and 48 h of ET treatment, the WBC and NE in mortality group were still higher than those in surviving group (P < 0.05). There were no statistically significant differences in WBC and NE between the two groups 72 h after ET treatment (P > 0.05). The levels of C-reactive protein (CRP), procalcitonin (PCT), N-terminal B-type natriuretic peptide precursor (NT-BNP), creatinine (Cr), lactate dehydrogenase (LDH), creatine kinase (CK), and myoglobin (MYO) in mortality group were all higher than those in surviving group before ET therapy (P < 0.05). The PH and PO
conclusionsET is an important treatment for improving the prognosis of infants with severe pertussis. Infants with severe pertussis who undergo ET have a higher peak WBC count, and those with concomitant pulmonary arterial hypertension, cardiac, renal, neurological dysfunction have a poorer prognosis. Early intervention and active treatment are necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.