Evidence map›Paper›PMID 41044692›Full record

ArticleBMC cancer2025

Expression and prognostic value of MCM2 in type B thymomas.

Xin Du, Jian Cui, Xintao Yu, Dingfang Cao, Ying Zhang, Lei Yu, Shanqing Li

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Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xin Du *Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Jian Cui *Department of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Xintao YuDepartment of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Dingfang CaoDepartment of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Ying ZhangDepartment of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Lei YuDepartment of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. yulei1118@sohu.com.
Shanqing LiDepartment of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China. lishanqing@pumch.cn.

Funding

Beijing Association for Science and Technology's "Golden-Bridge Seed Funding Program" ZZ22006National High Level Hospital Clinical Research Funding 2022-PUMCH-B-011
6 · The paper itself

Abstract

backgroundThymic epithelial tumors (TETs) are the most common mediastinal malignancies, lacking reliable prognostic biomarkers. This study aimed to identify a potential prognostic marker for TETs.

methodsmRNA microarray analysis of 30 tumor and peritumoral tissues identified differentially expressed genes (DEGs). Hub genes were selected via protein-protein interaction (PPI) analysis, with MCM2 chosen as the target gene. Survival and enrichment analyses were performed, and a validation cohort assessed MCM2's association with prognosis and clinicopathological features.

resultsSeven hundred thirty-four DEGs were identified, with MCM2 significantly associated with prolonged progression-free survival (PFS) (HR = 0.17; 95% CI: 0.05-0.54; p = 0.003) and identified as an independent risk factor for PFS (HR = 0.26; 95% CI: 0.08-0.91; p = 0.035). MCM2 expression decreased from type B1 to B3 thymomas.

conclusionsMCM2 is an independent prognostic factor for TETs, with higher expression linked to better PFS and decreasing expression across B-type thymomas, suggesting its role as a favorable prognostic marker.

Indexed as

Biomarkers, TumorMinichromosome Maintenance Complex Component 2ThymomaThymus NeoplasmsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasms, Glandular and EpithelialPrognosisProtein Interaction MapsBiomarkers, TumorMCM2 protein, humanMinichromosome Maintenance Complex Component 2MCM2Microarray analysisPrognosticProtein-protein interactionThymoma

Identifiers

PMID41044692
PMCPMC12495699

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