Evidence map›Paper›PMID 41044678›Full record

ArticleAnimal microbiome2025

Probiotic Bacillus subtilis enhances silkworm (Bombyx mori) growth performance and silk production via modulating gut microbiota and amino acid metabolism.

Chunjiu Ren, Yingchen Meng, Yangyang Liu, Yi Wang, Huizhen Wang, Yating Liu, Changjun Liu, Xin Fan, Shengxiang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunjiu Ren *Department of Sericulture, College of Forestry, Shandong Agricultural University, Taian, 271018, China. renchj2010@126.com.
Yingchen Meng *Department of Sericulture, College of Forestry, Shandong Agricultural University, Taian, 271018, China.
Yangyang LiuDepartment of Sericulture, College of Forestry, Shandong Agricultural University, Taian, 271018, China.
Yi WangDepartment of Sericulture, Sericulture and Edible Fungus Institute, Yibin Academy of Agricultural Sciences, Yibin, 644699, Sichuan, China.
Huizhen WangDepartment of Sericulture, College of Forestry, Shandong Agricultural University, Taian, 271018, China.
Yating LiuDepartment of Biotechnology and Engineering, College of Life Sciences, Shandong Agricultural University, Taian, 271018, China.
Changjun LiuDepartment of Sericulture, College of Forestry, Shandong Agricultural University, Taian, 271018, China.
Xin FanDepartment of Sericulture, College of Forestry, Shandong Agricultural University, Taian, 271018, China.
Shengxiang ZhangDepartment of Sericulture, College of Forestry, Shandong Agricultural University, Taian, 271018, China. zsx@sdau.edu.cn.

Funding

China Agriculture Research System of MOF and MARA No. CARS-18Modern Agricultural Technology System of Shandong Province No. SDAIT-18
6 · The paper itself

Abstract

backgroundArtificial diet-reared silkworms (Bombyx mori) exhibit reduced gut microbial diversity and impaired growth performance compared to mulberry-fed counterparts. While Bacillus subtilis is widely used as a probiotic in livestock and aquaculture, its impact on silkworms remains unexplored. This study investigates whether dietary supplementation with B. subtilis enhances larval development and elucidates the underlying mechanisms involving gut microbiota and metabolic pathways.

resultsSupplementing artificial diets with B. subtilis (6 × 10

conclusionsB. subtilis enhances silkworm growth and silk production through multi-faceted mechanisms: reshaping gut microbiota composition, improving digestive enzyme activity, and elevating phenylalanine biosynthesis. These findings establish B. subtilis as a promising probiotic for optimizing artificial diet systems in Lepidoptera and highlight the central role of amino acid metabolism in insect-microbiome symbiosis.

Indexed as

Amino acid metabolismArtificial dietBacillus subtilisGrowth promotionGut microbiotaSilkworm

Identifiers

PMID41044678
PMCPMC12495873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.