ArticleTropical diseases, travel medicine and vaccines2025
Global research trends in BPaL and BPaLM regimens for drug-resistant tuberculosis: a bibliometric analysis.
Article in Tropical diseases, travel medicine and vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evaluating treatment outcomes stratified by regimen among drug-resistant TB patients in Sierra Leone.Public health action · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe introduction of BPaL and BPaLM regimens has revolutionized drug-resistant tuberculosis treatment, offering superior efficacy, shorter duration, and better tolerability than conventional therapies. Despite their rapid WHO guideline incorporation, no prior bibliometric analysis has been conducted on this topic. This study addresses this gap by mapping global knowledge production, collaborations, and thematic trends to inform future research and implementation strategies.
methodsWe analyzed Scopus-indexed publications using controlled vocabulary for BPaL/BPaLM regimens. From 551 initial records, 120 met inclusion criteria after screening. Bibliometrix and VOS Viewer software evaluated publication trends, authorship, institutional/geographical contributions, citations, and keyword networks. Visualization tools mapped collaborations and thematic clusters, while statistical methods assessed growth rates and citation impacts.
resultsThe study identified 1,081 authors, with publications growing at 11.61% annually and peaking in 2024 (n = 56). International collaborations featured in 53.33% of studies, led by the US (n = 56), UK (n = 25), and South Africa (n = 20). Johns Hopkins University was the top institution (n = 56), and Antimicrobial Agents and Chemotherapy the leading journal (n = 15). Landmark 2019 publications had the highest citation rate (13.05/year). Thematic analysis revealed categorization into three domains: pathogen and drug resistance, treatment regimens and efficacy, and demographics and clinical studies. Strong collaborations linked high-income and high-burden countries, notably the US and South Africa.
conclusionThis first bibliometric assessment of BPaL/BPaLM research highlights progress in evidence generation but reveals gaps in implementation science and equitable knowledge production. Future work should address operational challenges, special populations, and resistance monitoring. These insights can guide researchers, policymakers, and funders to optimize TB control programs and advance global elimination goals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.