ArticleClinical epigenetics2025
Cadmium and Chromium exposure associated with DNA hypermethylation of p16 tumor suppressor gene: a case-control study from endemic region of northern India.
Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Heavy Metal-Contaminated Soils and Gastric Cancer Risk: Molecular Insights and the Relevance of a One Health Perspective.International journal of molecular sciences · 2025Review
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Authors and funding
4 authors.
Funding
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Abstract
This study investigates the environmental impact of urbanization on water quality in Greater Noida, a rapidly developing region in India. Thirty groundwater samples were collected from five villages during the pre-monsoon season using sterilized polypropylene bottles, and samples were acidified and digested with concentrated nitric acid prior to analysis. Chromium (Cr) and cadmium (Cd) concentrations in water were determined using Atomic Absorption Spectrophotometry (AAS), with mean pre-monsoon concentrations of 0.436 ± 0.237 ppb for Cr and 0.224 ± 0.091 ppb for Cd. A case-control study involving 25 cancer patients and 25 healthy individuals was conducted to explore the potential health effects of heavy metal exposure through drinking water. Blood samples were analyzed for Cd and Cr levels, and p16 gene promoter hypermethylation was assessed in whole blood leukocytes using methylation-specific PCR (MSP). The frequency of p16 hypermethylation was significantly higher in the exposed group (64%) compared to controls (8%) (p = 0.002). These findings demonstrate a strong association between heavy metal exposure and p16 hypermethylation, emphasizing the need for comprehensive monitoring, control measures, and remediation strategies to address environmental contamination and safeguard public health in swiftly urbanizing regions like Greater Noida.
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