ArticleBMC oral health2025
Fabrication of chitosan-based nanocomposites reinforced with zeolite and gold nanoparticles for enhanced bactericidal efficiency.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Effect of Home Bleaching Gel with Chitosan on Tooth Color and Mineral Alteration.Gels (Basel, Switzerland) · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
The development of novel antibacterial biomaterials is urgently needed to address infection, which is a key global issue that threatens human health. For this purpose, polymer-based nanocomposites augmented with nanoparticles have drawn attention as effective materials for antibacterial goals, offering bactericidal effectiveness and durability. This study presents a novel chitosan-based polymer nanocomposite augmented with zeolite and gold (Au) nanoparticles. The nanocomposite was prepared via a direct synthesis method. A thorough structural and morphological characterization was conducted on the nanocomposite. The findings demonstrated the interactions between the components and, in turn, the successful preparation of the nanocomposite. The bactericidal efficiency of the synthesized samples was assessed through the number of colony-forming units per millimetre (CFU/ml). The results confirmed the bactericidal activity of the synthesized samples against S. mutans. The samples synthesized in experiment 7 (chitosan 6 mg/ml, zeolite 3 mg/ml and Au 4.5 mg/ml) presented the lowest survival rate of S. mutans bacteria (0.24 log10 CFU/ml). Analysis of variance (ANOVA) revealed a contribution percentage of 51.28% for Au nanoparticles, which shows that Au nanoparticles contributed the most to the antibacterial performance of the nanocomposite. This was followed by 24.32% and 16.84% for chitosan and zeolite, respectively. The interaction effects further verified that the combination of third-level Au nanoparticles and chitosan had the most synergistic effects, which led to a 23.29% reduction in the survival rate of S.mutans. Overall, this nanocomposite holds significant potential in dental applications as an antibacterial agent. Nonetheless, toxicology assessments in vitro and in vivo are warranted, ensuring their biocompatibility before their clinical application.
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Registered trials
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