Evidence map›Paper›PMID 41044567›Full record

ArticleBMC oral health2025

Plasma cytokine profiles in oral and oropharyngeal squamous cell carcinoma.

Patnarin Mahattanasakul, Komkrit Ruangritchankul, Areeya Diloktaweewattana, Supranee Buranapraditkun, Nakarin Kitkumthorn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patnarin MahattanasakulDepartment of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.ORCID http://orcid.org/0000-0001-6552-5463
Komkrit RuangritchankulDepartment of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.ORCID http://orcid.org/0000-0003-2945-7760
Areeya DiloktaweewattanaTherapeutic Cell Production Unit, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, Thailand.ORCID http://orcid.org/0000-0001-6783-2643
Supranee BuranapraditkunDivision of Allergy and Clinical Immunology, Department of Medicine, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Thai Red Cross Society, 10330, Bangkok, Thailand. bsuprane2001@yahoo.com.ORCID http://orcid.org/0000-0001-9971-4318
Nakarin KitkumthornDepartment of Oral Biology, Faculty of Dentistry, Mahidol University, Yothi Road, 10400, Bangkok, Thailand. nakarinkit@gmail.com.ORCID http://orcid.org/0000-0003-0616-6039

Funding

Emerging Infectious Diseases and Vaccines Cluster, Ratchadapisek Sompoch Endowment Fund, Chulalongkorn University and the Second Century Fund (C2F), Chulalongkorn University 764002-HE04Ratchadapisek Sompoch Endowment Fund, Chulalongkorn University RA64/025
6 · The paper itself

Abstract

backgroundHead and neck cancers, including oral and oropharyngeal squamous cell carcinomas (SCC), impact significant global health challenges. This study aimed to evaluate plasma cytokine profiles in patients with oral and oropharyngeal SCC compared to healthy donors to explore potential diagnostic biomarkers.

methodsPlasma samples from 18 healthy donors, 11 oral cancer patients, and 11 oropharyngeal cancer patients were analysed using LEGENDplex™ multiplex assays to quantify 49 cytokines and inflammatory proteins. Statistical analysis, including Mann-Whitney U test and ROC curve analysis, was performed to assess diagnostic utility.

resultssFasL levels were significantly downregulated in cancer patients, whereas PECAM-1, FGF-basic, EPO, PDGF-AA, and PDGF-BB levels were upregulated. Combined analysis of PDGF-AA and PDGF-BB achieved a sensitivity of 98.38% and specificity of 73.87% for oral cancer diagnosis. PECAM-1 demonstrated 100% sensitivity for detecting oropharyngeal cancer.

conclusionThese preliminary findings suggest that alterations in plasma levels of sFasL, PECAM-1, FGF-basic, EPO, PDGF-AA, and PDGF-BB suggest their potential as early diagnostic markers for oral and oropharyngeal SCC. Larger cohort studies are warranted to validate these findings and to develop screening strategies for head and neck cancers.

trial registrationThe study protocol was approved by the Institutional Review Board of the Faculty of Medicine, Chulalongkorn University (IRB 810/62, Bangkok, Thailand) and adhered to the Declaration of Helsinki. Written informed consent was obtained from all participants.

Indexed as

Carcinoma, Squamous CellCytokinesMouth NeoplasmsOropharyngeal NeoplasmsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedPlatelet-Derived Growth FactorSensitivity and SpecificityBiomarkers, TumorCytokinesPlatelet-Derived Growth FactorBiomarkersCytokinesInflammationOral cancerOropharyngeal cancer

Identifiers

PMID41044567
PMCPMC12492868

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.